A novel approach to assessing bisphenol-A hazards using an in vitro model system

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• 作者：Md Saidur Rahman ; Woo-Sung Kwon ; Sung-Jae Yoon ; Yoo-Jin Park ; Buom-Yong Ryu…
• 关键词：Bisphenol ; A ; Health hazards ; In ; vitro ; Spermatozoa ; Proteomics ; Bioinformatics databases ; Diseases ; Signaling pathways
• 刊名：BMC Genomics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1864KB
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164
• 卷排序：17

文摘

BackgroundAlthough the toxicological impacts of the xenoestrogen bisphenol-A (BPA) have been studied extensively, but the mechanism of action is poorly understood. Eventually, no standard method exists for evaluating the possible health hazards of BPA exposure. Considering mice spermatozoa as a potential in vitro model, we investigated the effects of BPA exposure (0.0001, 0.01, 1, and 100 μM for 6 h) on spermatozoa and the related mechanisms of action. The same doses were also employed to evaluate protein profiles of spermatozoa as a means to monitor their functional affiliation to diseases.