The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma

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• 作者：Jingmin You (1) (2)
  Lu Lin (1)
  Qiong Liu (3)
  Tengfei Zhu (3)
  Kun Xia (3)
  Tong Su (1)
  
  1. Department of Oral and Maxillofacial Surgery ; Xiangya Hospital ; Central-South University ; Changsha ; 410008 ; China
  2. Department of Stomatology ; First People鈥檚 Hospital of Changde ; Changde ; 415003 ; Hunan ; China
  3. State Key Laboratory of Medical Genetics ; Central South University ; 110 Xiangya Road ; Changsha ; Hunan ; 410078 ; China
  
• 关键词：Differentiated embryo ; chondrocyte expressed gene l ; Immunohistochemistry ; Metastasis ; Oral squamous cell carcinoma ; Real ; time polymerase chain reaction ; Recurrence
• 刊名：European Journal of Medical Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：19
• 期：1
• 全文大小：271 KB
• 参考文献：1. Campo-Trapero, J, Cano-S谩nchez, J, Palacios-S谩nchez, B, Llamas-Mart铆nez, S, Lo Muzio, L, Bascones-Mart铆nez, A (2008) Cellular senescence in oral cancer and precancer and treatment implications: a review. Acta Oncol 47: pp. 1464-1474 CrossRef
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  10. Zheng, Y, Shi, X, Wang, M, Jia, Y, Li, B, Zhang, Y, Liu, Q, Wang, Y (2012) The increased expression of DEC1 gene is related to HIF-1alpha protein in gastric cancer cell lines. Mol Biol Rep 39: pp. 4229-4236 11033-011-1209-0" target="_blank" title="It opens in new window">CrossRef
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  12. Liu, Y, Miao, Y, Wang, J, Lin, X, Wang, L, Xu, HT, Wang, EH (2013) DEC1 is positively associated with the malignant phenotype of invasive breast cancers and negatively correlated with the expression of claudin-1. Int J Mol Med 31: pp. 855-860
  13. Qian, Y, Jung, YS, Chen, X (2012) DEC1 and MIC-1: new players of p53-dependent cell fate decision. Cell Cycle 11: pp. 3525-3526 CrossRef
  14. Wu, Y, Sato, F, Yamada, T, Bhawal, UK, Kawamoto, T, Fujimoto, K, Noshiro, M, Seino, H, Morohashi, S, Hakamada, K, Abiko, Y, Kato, Y, Kijima, H (2012) The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer. Int J Oncol 41: pp. 1337-1346
  
• 刊物主题：Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：2047-783X

文摘

Background This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment of OSCC. Methods The expression of DEC1 in tissues from 56 primary OSCC patients and 20 normal oral mucosa samples were detected using real-time polymerase chain reaction and immunohistochemical methods, respectively. Results The results showed that the positive expression rate of DEC1 in the OSCC group was significantly higher than that in the normal group (P P Conclusions The expression of DEC1 was associated with the incidence of OSCC and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.