A model-embedded trend test with incorporating Hardy-Weinberg equilibrium information

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• 作者：Xiaonan Hu ; Xiaogang Duan ; Dongdong Pan…
• 关键词：Genetic model ; hardy ; weinberg equilibrium ; power ; robust ; trend test
• 刊名：Journal of Systems Science and Complexity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：30
• 期：1
• 页码：101-110
• 全文大小：
• 刊物类别：Mathematics and Statistics
• 刊物主题：Systems Theory, Control; Operation Research/Decision Theory; Mathematics of Computing; Complex Systems; Statistics, general;
• 出版者：Academy of Mathematics and Systems Science, Chinese Academy of Sciences
• ISSN：1559-7067
• 卷排序：30

文摘

The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test.