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Pokemon promotes the invasiveness of hepatocellular carcinoma by enhancing MEF2D transcription
- 作者:Jing Kong ; Xiaoping Liu ; Xiangqian Li ; Jinsheng Wu ; Ning Wu…
- 关键词:Pokemon ; MEF2D ; HCC
- 刊名:Hepatology International
- 出版年:2016
- 出版时间:May 2016
- 年:2016
- 卷:10
- 期:3
- 页码:493-500
- 全文大小:1,462 KB
- 参考文献:1.Maeda T, Hobbs RM, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature 2005;433:278–285CrossRef PubMed
2.He S, Liu F, Xie Z, Zu X, Xu W, Jiang Y. P-Glycoprotein/MDR1 regulates pokemon gene transcription through p53 expression in human breast cancer cells. Int J Mol Sci 2010;11:3039–3051CrossRef 3.Lin CC, Zhou JP, Liu YP, Liu JJ, Yang XN, Jazag A, et al . The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3 K/Akt pathway. PLoS ONE 2012;7:e51916CrossRef PubMed PubMedCentral 4.Zhang QL, Tian DA, Xu XJ. Depletion of Pokemon gene inhibits hepatocellular carcinoma cell growth through inhibition of H-ras. Onkologie 2011;34:526–531CrossRef PubMed 5.Zhang YQ, Xiao CX, Lin BY, Shi Y, Liu YP, Liu JJ, et al. Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. PLoS ONE 2013;8:e68981CrossRef PubMed PubMedCentral 6.Liu K, Liu F, Zhang N, Liu S, Jiang Y. Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703. Int J Mol Sci 2012;13:5818–5831CrossRef PubMed PubMedCentral 7.Zhang NN, Sun QS, Chen Z, Liu F, Jiang YY. Homeostatic regulatory role of Pokemon in NF-kappaB signaling: stimulating both p65 and IkappaBalpha expression in human hepatocellular carcinoma cells. Mol Cell Biochem 2013;372:57–64CrossRef PubMed 8.Jin XL, Sun QS, Liu F, Yang HW, Liu M, Liu HX, et al. microRNA 21-mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation. J Cell Biochem 2013;114:1625–1633CrossRef PubMed 9.Ding Y, Wang W, Feng M, Wang Y, Zhou J, Ding X, et al. A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy. Biomaterials 2012;33:8893–8905CrossRef PubMed 10.Potthoff MJ, Olson EN. MEF2: a central regulator of diverse developmental programs. Development 2007;134:4131–4140CrossRef PubMed 11.Ma L, Liu J, Liu L, Duan G, Wang Q, Xu Y, et al. Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes. Cancer Res 2014;74:1452–1462CrossRef PubMed 12.Yu W, Huang C, Wang Q, Huang T, Ding Y, Ma C, et al. MEF2 transcription factors promotes EMT and invasiveness of hepatocellular carcinoma through TGF-beta1 autoregulation circuitry. Tumour Biol 2014;35:10943–10951CrossRef PubMed 13.Li W, Kidiyoor A, Hu Y, Guo C, Liu M, Yao X, et al. Evaluation of transforming growth factor-beta1 suppress Pokemon/epithelial-mesenchymal transition expression in human bladder cancer cells. Tumour Biol 2015;36:1155–1162CrossRef PubMed 14.Yang X, Zu X, Tang J, Xiong W, Zhang Y, Liu F, et al. Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: implications for the role of Zbtb7 in cell cycle regulation. Mol Med Rep 2012;5:1475–1480PubMed 15.Zu X, Ma J, Liu H, Liu F, Tan C, Yu L, et al. Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression. Breast Cancer Res 2011;13:R26CrossRef PubMed PubMedCentral
- 作者单位:Jing Kong (1)
Xiaoping Liu (1) Xiangqian Li (1) Jinsheng Wu (2) Ning Wu (3) Jun Chen (1) Fang Fang (1)
1. Faculty of Life Science and Chemical Engineering, Huaiyin Institute of Technology, 1 Meicheng Road East, Huai’an, 223003, Jiangsu, People’s Republic of China 2. Department of Hepatopancreatobiliary Surgery, Huai’an First People’s Hospital, Nanjing Medical University, 6 Beijing Road West, Huai’an, 223300, Jiangsu, People’s Republic of China 3. Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao, 266071, Shandong, People’s Republic of China
- 刊物主题:Hepatology; Colorectal Surgery; Surgery;
- 出版者:Springer India
- ISSN:1936-0541
文摘
Background Pokemon, a master oncogene crucial for the tumorigenicity and progression of a variety of cancers, has been demonstrated to enhance the proliferation and survival of hepatocellular carcinoma (HCC). However, the contribution of Pokemon to the invasiveness of HCC has not yet been studied.
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