CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury

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• 作者：Xinhui Zhu (1)
  Li Yao (1) (2) (3)
  Aisong Guo (2)
  Aihong Li (2)
  Huiqing Sun (2)
  Ning Wang (3)
  Hanzhang Liu (3)
  Zhiqin Duan (3)
  Jianhua Cao (2)
  
• 关键词：CAP1 ; Actin ; Schwann cells ; Differentiation ; Migration ; Sciatic nerve crush
• 刊名：Journal of Molecular Histology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：45
• 期：3
• 页码：337-348
• 全文大小：3,295 KB
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• 作者单位：Xinhui Zhu (1)
  Li Yao (1) (2) (3)
  Aisong Guo (2)
  Aihong Li (2)
  Huiqing Sun (2)
  Ning Wang (3)
  Hanzhang Liu (3)
  Zhiqin Duan (3)
  Jianhua Cao (2)
  
  1. Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China
  2. Department of Orthopaedics, Affiliated Mental Health Center of Nantong University, Nantong, 226001, People’s Republic of China
  3. Department of Immunology, Medical College, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China
  
• ISSN：1567-2387

文摘

Adenylate cyclase-associated protein 1 (CAP1), a member of cyclase-associated proteins that regulating actin dynamics, was shown to regulate actin filaments, localize to dynamic actin structures and mediate such processes as establishment of cell polarity, motility, morphogenesis, receptor-mediated endocytosis and mRNA location. But little is known about the role of CAP1 during peripheral nervous system injury. Here, we found the spatiotemporal protein expression of CAP1 after sciatic nerve crush. After crush, CAP1 had an increased protein expression level, reached a peak at about day 5 and then returned to the normal level at 4?weeks, similar to Oct-6. Besides, in 5-day injured tissue, using double immunofluorescent staining we found CAP1 had a colocalization with S100 and Oct-6. In vitro, during the process of cAMP-induced Schwann cells differentiation, we observed enhanced expression of CAP1 and P0. Specially, CAP1-specific siRNA-tranfected SCs did not show significant actin structure which form cellure surface tension and protrusion shape after cAMP treatment. And we observed the interaction of CAP1 with actin and that CAP1-specific siRNA-transfected SCs had a decreased motility and migration. Together, all these data indicated that the change of CAP1 protein expression was associated with Schwann cells motility and differentiation after the crush of sciatic nerve.