Prognostic value of CC-chemokine receptor seven expression in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitor

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• 作者：Yu Xia ; Li Liu ; Ying Xiong ; Qi Bai ; Jiajun Wang ; Wei Xi ; Yang Qu ; Jiejie Xu…
• 关键词：Metastatic renal cell carcinoma ; CC ; chemokine receptor 7 ; Overall survival ; Progression free survival ; Lymphatic invasion
• 刊名：BMC Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：1493KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2407
• 卷排序：17

文摘

BackgroundCC-chemokine receptor seven (CCR7), a G-protein coupled receptor normally facilitating immune cells lymphatic homing, has recently been identified on several cancer cells in promoting invasion and lymphatic specific metastasis by mimicking normal leukocytes. As tyrosine kinase inhibitors for metastatic renal cell carcinoma (mRCC) mostly emphasized on vascular inhibition, whether the CCR7 expressing tumor cells with potential lymphatic invasion function could have an impact on mRCC patient’s drug response and survival, was unknown.