The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

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• 作者：Brian A Hodge ; Yuan Wen ; Lance A Riley ; Xiping Zhang ; Jonathan H England…
• 关键词：Circadian ; Molecular clock ; Skeletal muscle ; Metabolism ; Temporal separation ; Anabolic ; Catabolic ; Bmal1 ; Rev ; erbα
• 刊名：Skeletal Muscle
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：5
• 期：1
• 全文大小：1,121 KB
• 刊物主题：Cell Biology; Developmental Biology; Biochemistry, general; Systems Biology; Biotechnology;
• 出版者：BioMed Central
• ISSN：2044-5040

文摘

Background Skeletal muscle is a major contributor to whole-body metabolism as it serves as a depot for both glucose and amino acids, and is a highly metabolically active tissue. Within skeletal muscle exists an intrinsic molecular clock mechanism that regulates the timing of physiological processes. A key function of the clock is to regulate the timing of metabolic processes to anticipate time of day changes in environmental conditions. The purpose of this study was to identify metabolic genes that are expressed in a circadian manner and determine if these genes are regulated downstream of the intrinsic molecular clock by assaying gene expression in an inducible skeletal muscle-specific Bmal1 knockout mouse model (iMS-Bmal1 −/− ).