Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development

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• 作者：Chun-Hui Zhang (1) (2)
  Wei-Ping Qian (1)
  Shu-Tao Qi (2)
  Zhao-Jia Ge (2)
  Ling-Jiang Min (2) (4)
  Xiu-Lang Zhu (2)
  Xin Huang (2)
  Jing-Ping Liu (1)
  Ying-Chun Ouyang (2)
  Yi Hou (2)
  Heide Schatten (3)
  Qing-Yuan Sun (2)
  
• 关键词：Endoplasmic reticulum ; Maternal diabetes ; Oocyte maturation ; Early embryo
• 刊名：Reproductive Biology and Endocrinology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：1377KB
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• 作者单位：Chun-Hui Zhang (1) (2)
  Wei-Ping Qian (1)
  Shu-Tao Qi (2)
  Zhao-Jia Ge (2)
  Ling-Jiang Min (2) (4)
  Xiu-Lang Zhu (2)
  Xin Huang (2)
  Jing-Ping Liu (1)
  Ying-Chun Ouyang (2)
  Yi Hou (2)
  Heide Schatten (3)
  Qing-Yuan Sun (2)
  
  1. Department of Reproductive Medicine, Peking University Shenzhen Hospital, Medical Center of Peking University, Shenzhen, Guangdong, China
  2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
  4. College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
  3. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65211, USA
  

文摘

Background The adverse effects of maternal diabetes on oocyte maturation and embryo development have been reported. Methods In this study, we used time-lapse live cell imaging confocal microscopy to investigate the dynamic changes of ER and the effects of diabetes on the ER’s structural dynamics during oocyte maturation, fertilization and early embryo development. Results We report that the ER first became remodeled into a dense ring around the developing MI spindle, and then surrounded the spindle during migration to the cortex. ER reorganization during mouse early embryo development was characterized by striking localization around the pronuclei in the equatorial section, in addition to larger areas of fluorescence deeper within the cytoplasm. In contrast, in diabetic mice, the ER displayed a significantly higher percentage of homogeneous distribution patterns throughout the entire ooplasm during oocyte maturation and early embryo development. In addition, a higher frequency of large ER aggregations was detected in GV oocytes and two cell embryos from diabetic mice. Conclusions These results suggest that the diabetic condition adversely affects the ER distribution pattern during mouse oocyte maturation and early embryo development.