Preimplantation genetic screening of blastocysts by multiplex qPCR followed by fresh embryo transfer: validation and verification

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• 作者：Yu-Shih Yang ; Shun-Ping Chang ; Hsin-Fu Chen ; Gwo-Chin Ma…
• 关键词：Aneuploidy ; Blastocyst ; Fresh embryo transfer ; PGS ; qPCR
• 刊名：Molecular Cytogenetics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：8
• 期：1
• 全文大小：1,104 KB
• 刊物主题：Cytogenetics; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1755-8166

文摘

Background Aneuploidy is an important etiology of implantation failure and quantitative real-time polymerase chain reaction (qPCR) seems a promising preimplantation genetic screening (PGS) technology to detect aneuploidies. This verification study aimed at verifying the impact on reproductive outcomes in in vitro fertilization (IVF) cycles using fresh embryo transfer (FET) in which the embryos were selected by blastocyst biopsy with qPCR-based PGS in our settings.