Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells

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• 作者：Cheng-Yu Yang ; Chih-Kung Lin ; Gu-Jiun Lin ; Cheng-Chih Hsieh…
• 关键词：Triptolide ; Chemoprevention ; Co ; inoculate ; U937 cell ; Oral cancer cell
• 刊名：Clinical Oral Investigations
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：419-427
• 全文大小：1202KB
• 刊物类别：Medicine
• 刊物主题：Dentistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1436-3771
• 卷排序：21

文摘

ObjectivesAdvanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC).