Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages

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• 作者：Lei Zhang ; Yi-Jing Han ; Xian Zhang ; Xin Wang ; Bin Bao ; Wei Qu ; Jian Liu
• 关键词：Adipose tissue macrophage ; AMPKα1 ; Insulin resistance ; Luteolin ; Polarisation
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：59
• 期：10
• 页码：2219-2228
• 全文大小：1,745 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428
• 卷排序：59

文摘

Aims/hypothesisInflammatory polarisation of adipose tissue macrophages (ATMs) plays a critical role in the development of obesity-associated metabolic diseases such as insulin resistance and diabetes. Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). Here, we further investigated the effects of LU, which is a natural flavonoid, on pre-established insulin resistance and obesity-associated ATM polarisation in mice.