Aerobic vaginitis and mixed infections: comparison of clinical and laboratory findings

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• 作者：Aiping Fan (1)
  Yingli Yue (1)
  Nv Geng (1)
  Huiying Zhang (1)
  Yingmei Wang (1)
  Fengxia Xue (1)
  
• 关键词：Aerobic vaginitis ; Diagnosis ; Mixed infections ; Clinical features
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：287
• 期：2
• 页码：329-335
• 全文大小：172KB
• 参考文献：1. Donders GGG, Vereecken A, Bosmans E, Dekeersmaecker A, Salembier G, Spitz B (2002) Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. Br J Obstet Gynecology 109:1-0 CrossRef
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  13. Tempera G, Bonfiglio G, Cammarata E, Corsello S, Cianci A (2004) Microbiological/clinical characteristics and validation of topical therapy with kanamycin in aerobic vaginitis: a pilot study. Int J Antimicrob Agents 24:85-8 CrossRef
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• 作者单位：Aiping Fan (1)
  Yingli Yue (1)
  Nv Geng (1)
  Huiying Zhang (1)
  Yingmei Wang (1)
  Fengxia Xue (1)
  
  1. Department of Gynecology, Tianjin Medical University General Hospital, Tianjin, 300052, China
  
• ISSN：1432-0711

文摘

Purpose To investigate the clinical features of aerobic vaginitis (AV) and mixed infections with AV to achieve efficient diagnosis. Methods From April 2008 to August 2009, 657 consecutive outpatients with vaginal symptoms in gynecology clinic in the General Hospital of Tianjin Medical University were investigated. Samples were taken for examination of vaginal discharge and fresh wet mount microscopy. AV, bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomonal vaginitis (TV) were diagnosed according to standardized definitions. Sixty patients with single AV were randomly selected over the same period. Each patient accepted moxifloxacin therapy. Two kinds of treatment course (400?mg qd, 6?days or 400?mg qd, 12?days) were given. Clinical features and laboratory test results in the first visit and follow-ups were recorded and statistically analyzed. Result Among the 657 cases, AV was found in 23.74?% of the cases (156/657). AV mixed infections were diagnosed in 53.85?% (84/156): the mixed infections included VVC (32/84, 38.10?%), BV (31/84, 36.90?%), and TV (21/84, 25.00?%). Common symptoms of AV were a change in the characteristics of the discharge (44/72, 61.11?%) and increased discharge (30/72, 41.67?%). Vaginal pH was usually higher than 4.5 (63/72, 87.50?%). Enterococcus faecalis, Streptococcus viridans, Escherichia coli, and Staphylococcus epidermidis were frequently isolated. There is no statistically significant difference between two moxifloxacin treatment groups (p?>?0.05). Cure rate was 89.7?% in 6-day group, and 71.4?% in 12-day group. Conclusions AV is a common vaginal infection, and it is often mixed with other infections, especially VVC, BV and TV. The symptoms and signs of AV mixed infections are atypical. If a patient has vaginal complaints, it is necessary to determine whether AV or mixed infections are present. Oral moxifloxacin is effective in treating AV, and an appropriate course should be selected taking the severity of AV into consideration.