l-Ribose isomerase and mannose-6-phosphate isomerase: properties and applications for l-ribose production

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• 作者：Zheng Xu ; Yuanyuan Sha ; Chao Liu ; Sha Li…
• 关键词：l ; Ribose ; l ; Ribose isomerase ; Mannose ; 6 ; phosphate isomerase ; Hepatitis B virus ; l ; Sugar
• 刊名：Applied Microbiology and Biotechnology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：100
• 期：21
• 页码：9003-9011
• 全文大小：516 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Microbiology
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0614
• 卷排序：100

文摘

l-Ribose is a synthetic l-form monosaccharide. It is a building block of many novel nucleotide analog anti-viral drugs. Bio-production of l-ribose relies on a two-step reaction: (i) conversion of l-arabinose to l-ribulose by the catalytic action of l-arabinose isomerase (l-AI) and (ii) conversion of l-ribulose to l-ribose by the catalytic action of l-ribose isomerase (l-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Between the two enzymes, l-RI is a rare enzyme that was discovered in 1996 by Professor Izumori’s group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms. Recent studies have focused on their potentials for industrial production of l-ribose. This review summarizes the applications of l-RI and MPI for l-ribose production.