IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance

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• 作者：Xueyan Zhang (1)
  Jiayuan Sun (1)
  Huimin Wang (1)
  Yuqing Lou (1)
  Yanwei Zhang (1)
  Huifang Sha (2)
  Jiuxian Feng (2)
  Baohui Han (1)
  
• 关键词：Lung adenocarcinoma ; IGF ; 1R ; Bmi ; 1 ; Immunohistochemistry ; Prognosis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：35
• 期：1
• 页码：739-745
• 全文大小：516 KB
• 作者单位：Xueyan Zhang (1)
  Jiayuan Sun (1)
  Huimin Wang (1)
  Yuqing Lou (1)
  Yanwei Zhang (1)
  Huifang Sha (2)
  Jiuxian Feng (2)
  Baohui Han (1)
  
  1. Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, No. 241, West Huaihai Rd, 200030, Shanghai, China
  2. Basic Research Laboratory, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China
  
• ISSN：1423-0380

文摘

IGF-1R and Bmi-1 play a critical role in cancer growth and survival. We explored the correlation between IGF-1R and Bmi-1, as well as their relationship with clinicopathological parameters and their impacts on outcomes in patients with lung adenocarcinoma resected. Tumors from 178 surgical lung adenocarcinoma patients were evaluated for IGF-1R and Bmi-1 expression by means of immunohistochemistry. The clinicopathological implications of these molecules were analyzed statistically. There was a significant correlation between the expression of IGF-1R and Bmi-1 (p--.011). The 5-year survival rate of patients with Bmi-1 positive was only 31.2?%, but patients with Bmi-1 negative had a survival rate of 50.7?% (p--.004). The pattern of survival curves showed that Bmi-1 was a significant prognostic factor of poor overall survival in lung adenocarcinoma patients. However, there was no obvious correlation between IGF-1R expression and patient survival. The results of multivariate Cox analysis revealed that the pathological stages and Bmi-1 expression were independent prognostic factors. Therefore, Bmi-1 may be a good biomarker to predict the prognosis of patients with completely resected lung adenocarcinoma.