Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism
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  • 作者：Fancong Kong (1)
    Zhichao Chen (1)
    Qiubai Li (1)
    Xiaolong Tian /a> (1)
    Juan Zhao (1)
    Ke Yu (1)
    Yong You (1)
    Ping Zou (1)
  • 关键词：parthenolide ; multiple myeloma ; angiogenesis ; NF ; kappaB activity ; VEGF ; IL ; 6 ; MMPs
  • 刊名：Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 出版年：2008
  • 出版时间：October 2008
  • 年：2008
  • 卷：28
  • 期：5
  • 页码：525-530
  • 全文大小：521KB
  • 参考文献：1. San Miguel J F, Blade Creixenti J, Garcia-Sanz R. Treatment of multiple myeloma. Haematologica, 1999,84:36-8
    2. Martinelli G, Terragna C, Zamagni E / et al. Molecular remission after allogeneic or autologous transplantation of hematopoietic stem cells for multiple myeloma. J Clin Oncol, 2000,18:2273-281
    3. Cavo M, Terragna C, Martinelli G / et al. Molecular monitoring of minimal residual disease in patients in long-term complete remission after allogeneic stem cell transplantation for multiple myeloma. Blood, 2000,96:355-57
    4. Lemoli R M, Martinelli G, Zamagni E / et al. Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy. Blood, 2000,95:2234-239
    5. Folkman J. Clinical applications of research on angiogenesis. N Engl J Med, 1995,333:1757-763 CrossRef
    6. Folkman J. New perspectives in clinical oncology from angiogenesis research. Eur J Cancer, 1996,14:2534-539 CrossRef
    7. Vacca A, Ribatti D, Roncali L / et al. Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol, 1994,87:503-08 CrossRef
    8. Rajkumar S V, Fonseca R, Witzig T E / et al. Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma. Leukemia (Baltimore), 1999,13:469-72
    9. Kim Y M, Kim Y M, Lee Y M / et al. TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the Activation of Src and Phospholipase C (PLC) in human endothelial cells. J Biol Chem, 2002,277:6799-805 CrossRef
    10. Yahata Y, Shirakata Y, Tokumaru S / et al. Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem, 2003,278:40 026-0 031 CrossRef
    11. Kwok B H, Koh B, Ndubuisi M I / et al. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol, 2001,8:759-66 CrossRef
    12. Yip-Schneider M T, Nakshatri H, Sweeney C J / et al. Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-KB pathway in pancreatic carcinoma cells. Mol Cancer Ther, 2005,4(4):587-94 CrossRef
    13. Zhang S Y, Lin Z N, Yang C F / et al. Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-α-induced apoptosis in human cancer cells. Carcinogenesis, 2004,25(11):2191-199 CrossRef
    14. Wen J, You K R, Lee S Y / et al. Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem, 2002,277(41):38 954-8 964 CrossRef
    15. Won Y K, Ong C N, Shi X L / et al. Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis, 2004,25(8):1449-458 CrossRef
    16. Chen Z C, Li Q B, Shao J / et al. Proliferation inhibiting and apoptosis inducing effects of parthenolide on human multiple myeloma cells. Natl Med J China (Chinese), 2006,86(28):1993-996
    17. Dankbar B, Padro T, Leo R / et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood, 2000,95:2630-636
    18. Bellamy W T, Richter L, Frutiger Y / et al. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res, 1999,59:728-33
    19. Zhang L, Chen S L, Chen W M / et al. The interaction of vascular endothelial growth factor and interleukin-6 in multiple myeloma. Chin J Intern Med (Chinese), 2005,44(2):85-8
    20. Ishikawa T Y, Ichikawa M, Mitsuhashi N / et al. Matrilysin is associated with progression of colorectal tumor. Cancer Lett, 1996,107:5-2 CrossRef
    21. Vacca A, Ribatt i D, Presta M / et al. Bone marrow neovascularization. Plasma cell angiogenic potential and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood, 1999,93(9):3064-072
    22. Song X K, Pan F J. Biological activity of parthenolilde and NF-kappa B channel inhibition. Chin J Gerontol (Chinese), 2003,12(23):892-93
  • 作者单位：Fancong Kong (1)
    Zhichao Chen (1)
    Qiubai Li (1)
    Xiaolong Tian /a> (1)
    Juan Zhao (1)
    Ke Yu (1)
    Yong You (1)
    Ping Zou (1)

    1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
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