Synthesis and characterization of UPPE-PLGA-rhBMP2 scaffolds for bone regeneration
详细信息    查看全文
  • 作者:Zhichao Tian (1) (2)
    Yuanli Zhu (3)
    Jinjun Qiu (4)
    Hanfeng Guan (1)
    Liangyu Li (1)
    Shouchao Zheng (1)
    Xuehai Dong (1)
    Jun Xiao (1)
  • 关键词:poly (lactic ; co ; glycolic acid) microspheres ; bone morphogenetic protein ; 2 ; unsaturated polyphosphoester ; bone regeneration
  • 刊名:Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 出版年:2012
  • 出版时间:August 2012
  • 年:2012
  • 卷:32
  • 期:4
  • 页码:563-570
  • 全文大小:616KB
  • 参考文献:1. Janicki P, Schmidmaier G. What should be the characteristics of the ideal bone graft substitute Combining scaffolds with growth factors and/or stem cells. Injury, 2011,42(Supplement 2):S77–S81 CrossRef
    2. Holzwarth JM, Ma PX. Biomimetic nanofibrous scaffolds for bone tissue engineering. Biomaterials, 2011,32(36): 9622-629 CrossRef
    3. Butscher A, Bohner M, Hofmann S, / et al. Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing. Acta Biomaterialia, 2011,7(3):907-20 CrossRef
    4. Rezwan K, Chen QZ, Blaker JJ, / et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials, 2006,27(18): 3413-431 CrossRef
    5. Tian H, Tang Z, Zhuang X, / et al. Biodegradable synthetic polymers: Preparation, functionalization and biomedical application. Prog Polym Sci, 2012,37(2):237-80 CrossRef
    6. Navarro M, Michiardi A, Castao O, / et al. Biomaterials in orthopaedics. J R Soc Interface, 2008,5(27):1137-158 CrossRef
    7. Puppi D, Chiellini F, Piras AM, / et al. Polymeric materials for bone and cartilage repair. Prog Polym Sci, 2010,35(4): 403-40 CrossRef
    8. Qiu J, Liu C, Hu F, / et al. Synthesis of unsaturated polyphosphoester as a potential injectable tissue engineering scaffold materials. J Appl Polym Sci, 2006,102(4):3095-101 CrossRef
    9. Li B, Yoshii T, Hafeman AE, / et al. The effects of rhBMP-2 released from biodegradable polyurethane/ microsphere composite scaffolds on new bone formation in rat femora. Biomaterials, 2009,30(35):6768-779 CrossRef
    10. Chaubal MV, Su G, Spicer E, / et al. In vitro and / in vivo degradation studies of a novel linear copolymer of lactide and ethylphosphate. J Biomater Sci Polym Ed, 2003,14(1):45-1 CrossRef
    11. Wang D, Williams CG, Li Q, / et al. Synthesis and characterization of a novel degradable phosphate-containing hydrogel. Biomaterials, 2003,24(22):3969-980 CrossRef
    12. Zhao Z, Wang J, Mao HQ, / et al. Polyphosphoesters in drug and gene delivery. Adv Drug Deliv Rev, 2003,55(4):483-99 CrossRef
    13. Mistry AS, Mikos AG, Jansen JA. Degradation and biocompatibility of a poly(propylene fumarate)-based/ alumoxane nanocomposite for bone tissue engineering. J Biomed Mater Res Part A, 2007,83A(4): 940-53 CrossRef
    14. Kikuchi M, Koyama Y, Takakuda K, / et al. In vitro change in mechanical strength of β-tricalcium phosphate/ copolymerized poly-L-lactide composites and their application for guided bone regeneration. J Biomed Mater Res, 2002,62(2):265-72 CrossRef
    15. Chen D, Zhao M, Mundy G. Bone morphogenetic proteins. Growth Factors, 2004,22(4):233-41 CrossRef
    16. Wong C, Inman E, Spaethe R, / et al. Fibrin-based biomaterials to deliver human growth factors. Thromb Haemost, 2003,89(3):573-82
    17. Wu G, Hunziker EB, Zheng Y, / et al. Functionalization of deproteinized bovine bone with a coating-incorporated depot of BMP-2 renders the material efficiently osteoinductive and suppresses foreign-body reactivity. Bone, 2011,49(6):1323-330 CrossRef
    18. Yilgor P, Tuzlakoglu K, Reis RL. Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials, 2009,30(21):3551-559 CrossRef
    19. Lee S, Shin H. Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv Drug Deliver Rev, 2007,59(4-):339-59 CrossRef
    20. Ratanavaraporn J, Furuya H, Kohara H, / et al. Synergistic effects of the dual release of stromal cell-derived factor-1 and bone morphogenetic protein-2 from hydrogels on bone regeneration. Biomaterials, 2011,32(11):2797-811 CrossRef
    21. Luo T, Zhang W, Shi B, / et al. Enhanced bone regeneration around dental implant with bone morphogenetic protein 2 gene and vascular endothelial growth factor protein delivery. Clin Oral Implants Res, 2012,23(4):467-73 CrossRef
    22. Manaka T, Suzuki A, Takayama K, / et al. Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation. Biomaterials, 2011,32(36):9642-648 CrossRef
    23. Jeon O, Kang S, Lim H, / et al. Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(l-lactide-co-glycolide) nanospheres and fibrin gel. Biomaterials, 2006,27(8):1598-607 CrossRef
    24. Winn SR, Uludag H, Hollinger JO. Sustained release emphasizing recombinant human bone morphogenetic protein-2. Adv Drug Deliver Rev, 1998,31(3):303-18 CrossRef
    25. Boerckel JD, Kolambkar YM, Dupont KM, / et al. Effects of protein dose and delivery system on BMP-mediated bone regeneration. Biomaterials, 2011,32(22):5241-251 CrossRef
    26. Lee JW, Kang KS, Lee SH, / et al. Bone regeneration using a microstereolithography-produced customized poly(propylene fumarate)/diethyl fumarate photopolymer 3D scaffold incorporating BMP-2 loaded PLGA microspheres. Biomaterials, 2011,32(3):744-52 CrossRef
    27. Zhang Z, Feng X, Mao J, / et al. In vitro cytotoxicity of a novel injectable and biodegradable alveolar bone substitute. Biochem Bioph Res Co, 2009,379(2):557-61 CrossRef
    28. Kempen DHR, Lu L, Kim C, / et al. Controlled drug release from a novel injectable biodegradable microsphere/ scaffold composite based on poly(propylene fumarate). J Biomed Mater Res Part A, 2006,77A(1):103-11 CrossRef
    29. Kempen DH, Kruyt MC, Lu L, / et al. Effect of autologous bone marrow stromal cell seeding and bone morphogenetic protein-2 delivery on ectopic bone formation in a microsphere/poly(propylene fumarate) composite. Tissue Eng Part A, 2009,15(3):587-94 CrossRef
    30. Li Q, Wang J, Shahani S, / et al. Biodegradable and photocrosslinkable polyphosphoester hydrogel. Biomaterials, 2006,27(7):1027-034 CrossRef
    31. Berkland C, Kipper MJ, Narasimhan B, / et al. Microsphere size, precipitation kinetics and drug distribution control drug release from biodegradable polyanhydride microspheres. J Control Release, 2004,94(1):129-41 CrossRef
    32. Han B, Wang H, Liu H, / et al. Preparation of pingyangmycin PLGA microspheres and related / in vitro/ / in vivo studies. Int J Pharm, 2010,398(1-):130-36 CrossRef
    33. Song X, Zhao Y, Wu W, / et al. PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: Systematic study of particle size and drug entrapment efficiency. Int J Pharm, 2008,350(1-): 320-29 CrossRef
    34. Dawson JI, Oreffo ROC. Bridging the regeneration gap: Stem cells, biomaterials and clinical translation in bone tissue engineering. Arch Biochem Biophys, 2008,473(2): 124-31 CrossRef
    35. Dietmar WH. Scaffolds in tissue engineering bone and cartilage. Biomaterials, 2000,21(24):2529-543 CrossRef
    36. Cao H, Kuboyama N. A biodegradable porous composite scaffold of PGA/β-TCP for bone tissue engineering. Bone, 2010,46(2):386-95 CrossRef
    37. Seeherman H, Li R, Bouxsein M, / et al. rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations. J Bone Joint Surg Am, 2006,88(1): 144-60 CrossRef
    38. Kim SS, Gwak SJ, Kim BS. Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/ hydroxyapatite composite particulates and bone morphogenetic protein-2. J Biomed Mater Res A, 2008,87(1):245-53
    39. Sun J, Dai Z, Zhao Y, / et al. In vitro effect of oligo-hydroxyalkanoates on the growth of mouse fibroblast cell line L929. Biomaterials, 2007,28(27):3896-903 CrossRef
    40. Skotak M, Leonov A, Larsen G, / et al. Biocompatible and biodegradable ultrafine fibrillar scaffold materials for tissue engineering by facile grafting of L-lactide onto chitosan. Biomacromolecules, 2008,9(7):1902-908 CrossRef
    41. Paillard-Giteau A, Tran VT, Thomas O, / et al. Effect of various additives and polymers on lysozyme release from PLGA microspheres prepared by an s/o/w emulsion technique. Eur J Pharm Biopharm, 2010,75(2):128-36 CrossRef
    42. Song I, Kim BS, Kim CS, / et al. Effects of BMP-2 and vitamin D3 on the osteogenic differentiation of adipose stem cells. Biochem Biophys Res Commun, 2011,408(1): 126-31 CrossRef
    43. Yilgor P, Tuzlakoglu K, Reis RL, / et al. Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials, 2009,30(21):3551-559 CrossRef
  • 作者单位:Zhichao Tian (1) (2)
    Yuanli Zhu (3)
    Jinjun Qiu (4)
    Hanfeng Guan (1)
    Liangyu Li (1)
    Shouchao Zheng (1)
    Xuehai Dong (1)
    Jun Xiao (1)

    1. Department of Orthopaedics, Huazhong University of Science and Technology, Wuhan, 430030, China
    2. Department of Musculoskeletal Tumor, Henan Cancer Hospital, Zhengzhou University, Zhengzhou, 450008, China
    3. Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    4. Department of Chemistry, Huazhong University of Science and Technology, Wuhan, 430074, China
文摘
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.