Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

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• 作者：Henrietta M. Nielsen ; Kewei Chen ; Wendy Lee ; Yinghua Chen…
• 关键词：Apolipoprotein E ; Dementia ; Plasma ; Cognition ; Gray matter volume
• 刊名：Alzheimer's Research & Therapy
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：9
• 期：1
• 全文大小：3113KB
• 刊物主题：Neurosciences; Neurology; Geriatrics/Gerontology; Geriatric Psychiatry;
• 出版者：BioMed Central
• ISSN：1758-9193
• 卷排序：9

文摘

BackgroundCarriers of the APOE ε4 allele are at increased risk of developing Alzheimer’s disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels of apolipoprotein E (apoE) attributed to a specific decrease in the apoE4 isoform as determined by quantification of individual apoE isoforms in APOE ε4 heterozygotes. Whether low plasma apoE levels are associated with structural and functional brain measurements and cognitive performance remains to be investigated.