Comparative biological evaluation between ^99mTc(CO)₃ and ^99mTc-Sn (II) complexes of novel quinoline derivative: a promising infection radiotracer

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• 作者：M. H. Sanad ; A. S. A. El-Bayoumy…
• 关键词：Labeling ; 99mTc ; Tricarbonyl core ; Quinoline derivative ; Infection
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：311
• 期：1
• 页码：1-14
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nuclear Chemistry; Physical Chemistry; Nuclear Physics, Heavy Ions, Hadrons; Diagnostic Radiology; Inorganic Chemistry;
• 出版者：Springer Netherlands
• ISSN：1588-2780
• 卷排序：311

文摘

A novel quinoline derivative, 2,2′-[(5-chloro-8-hydroxyquinoline-7-yl) methylazanediyl] diacetic acid (CHQMADA) was labeled with 99mTc using SnCl₂·2H₂O as a reducing agent to give a complex with a labeling yield 94 %. Also [99mTc(H₂O)₃(CO)₃]+ was prepared by heating at 100 °C for 30 min using 2 mg CHQMADA at pH 8 to give a labeling yield >99 %. 99mTc-(CO)₃ CHQMADA and 99mTc-Sn(II)-CHQMADA showed tissue uptake (target to non target T/NT = 6.80 ± 0.22) and (T/NT = 5.65 ± 0.34) respectively in Escherichia coli induced infection, which is higher than the commercially available 99mTc-ciprofloxacin (T/NT = 3.80 ± 0.80). In conclusion, both complexes were able to differentiate between septic and aseptic inflammation with superiority of [99mTc-(CO)₃ CHQMADA].