Acute effects of various antibiotic combinations on acetoclastic methanogenic activity

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• 作者：E. Gozde Ozbayram ; Osman Arikan ; Bahar Ince…
• 关键词：Acetoclastic methanogens ; Acute inhibition ; Anaerobic treatment ; Antibiotic mixture ; Biogas ; Combined effect
• 刊名：Environmental Science and Pollution Research
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：22
• 期：8
• 页码：6230-6235
• 全文大小：749 KB
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• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment
  Environment
  Atmospheric Protection, Air Quality Control and Air Pollution
  Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
  Industrial Pollution Prevention
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1614-7499

文摘

Pharmaceutical production industries are one of the main sources of antibiotics, and they release considerable amounts of antibiotics to ecosystem. Antibiotics usually present as mixtures in treatment plants and have negative effect on biological processes. In this study, batch acute tests were performed to assess the inhibitory impacts of selected antibiotic combinations of sulfamethoxazole and tetracycline (ST), erythromycin and sulfamethoxazole (ES), and erythromycin and tetracycline (ET) on acetoclastic methanogenic activity. Each antibiotic was equally applied, making the total concentrations in the mixtures 0 (control), 2, 20, 50, 100, 250, and 500?mg/L. Results showed decline characteristic on methane production with increasing antibiotic concentrations. EC50 values were calculated as 275?mg/L for ES, 219?mg/L for ST, and 130?mg/L for ET. Mixture inhibition of ST and ET combinations were accurately predicted using the concept of independent action, while ES combination resulted in almost the same inhibition with that of single antibiotic response. Inhibition on acetate utilization followed similar trend with methane production inhibition.