Fallstricke bei der histopathologischen Diagnostik des Endometriumkarzinoms und seiner Vorstufen

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• 作者：Prof. Dr. F. Kommoss ; S. F. Lax
• 关键词：SchlüsselwörterEndometriumhyperplasie ; Endometrioides Adenokarzinom ; Adenomyom ; Hyperplasie ; Fehldiagnosen
• 刊名：Der Pathologe
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：37
• 期：6
• 页码：512-520
• 全文大小：3,380 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1963
• 卷排序：37

文摘

Making an incorrect histopathological diagnosis of an endometrial lesion may lead to unwanted loss of fertility and therapy-associated morbidity; therefore, endometrial carcinomas need to be correctly typed and differentiated from hyperplastic precursors, benign lesions and artifacts. Typical diagnostic pitfalls are described in this article. Misdiagnosing endometrial lesions can be avoided by paying thorough attention to gross as well as microscopic features and by taking crucial differential diagnoses into consideration. These are, in particular, well-differentiated endometrioid adenocarcinoma of the endometrium versus atypical endometrial hyperplasia, myoinvasive endometrioid adenocarcinoma versus atypical polypoid adenomyoma and endometrioid carcinoma versus serous carcinoma of the endometrium with a predominantly glandular pattern. It is also important to consider the possibility of a false positive diagnosis of atypical endometrial hyperplasia or carcinoma in cases of biopsy-induced artifacts.