Na?ve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus

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• 作者：Rosanna Vescovini (1)
  Francesco Fausto Fagnoni (2)
  Anna Rita Telera (1)
  Laura Bucci (3) (4)
  Mario Pedrazzoni (1)
  Francesca Magalini (1)
  Adriano Stella (1)
  Federico Pasin (1)
  Maria Cristina Medici (1)
  Adriana Calderaro (1)
  Riccardo Volpi (1)
  Daniela Monti (5)
  Claudio Franceschi (3) (4)
  Janko Nikolich-?ugich (6)
  Paolo Sansoni (1)
  
• 关键词：Aging ; Age ; Cytomegalovirus ; Homeostasis ; Memory CD8 T cell ; Na?ve CD8 T cell
• 刊名：AGE
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：36
• 期：2
• 页码：625-640
• 全文大小：1,544 KB
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• 作者单位：Rosanna Vescovini (1)
  Francesco Fausto Fagnoni (2)
  Anna Rita Telera (1)
  Laura Bucci (3) (4)
  Mario Pedrazzoni (1)
  Francesca Magalini (1)
  Adriano Stella (1)
  Federico Pasin (1)
  Maria Cristina Medici (1)
  Adriana Calderaro (1)
  Riccardo Volpi (1)
  Daniela Monti (5)
  Claudio Franceschi (3) (4)
  Janko Nikolich-?ugich (6)
  Paolo Sansoni (1)
  
  1. Department of Clinical and Experimental Medicine, University of Parma, via Gramsci 14, 43126, Parma, Italy
  2. Immunohematology and Transfusion Center, Hospital of Parma, Parma, Italy
  3. Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
  4. Interdepartmental Centre for Studies on Biophysics, Bioinformatics and Biocomplexity L. Galvani (CIG), University of Bologna, Bologna, Italy
  5. Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
  6. Department of Immunobiology and the Arizona Center on Aging, College of Medicine, University of Arizona, Tucson, AZ, USA
  
• ISSN：1574-4647

文摘

Alterations in the circulating CD8+ T cell pool, with a loss of na?ve and accumulation of effector/effector memory cells, are pronounced in older adults. However, homeostatic forces that dictate such changes remain incompletely understood. This observational cross-sectional study explored the basis for variability of CD8+ T cell number and composition of its main subsets: na?ve, central memory and effector memory T cells, in 131 cytomegalovirus (CMV) seropositive subjects aged over 60?years. We found great heterogeneity of CD8+ T cell numbers, which was mainly due to variability of the CD8-?CD28?T cell subset regardless of age. Analysis, by multiple regression, of distinct factors revealed that age was a predictor for the loss in absolute number of na?ve T cells, but was not associated with changes in central or effector memory CD8+ T cell subsets. By contrast, the size of CD8+ T cells specific to pp65 and IE-1 antigens of CMV, predicted CD28???CD8+ T cell, antigen-experienced CD8+ T cell, and even total CD8+ T cell numbers, but not na?ve CD8+ T cell loss. These results indicate a clear dichotomy between the homeostasis of na?ve and antigen-experienced subsets of CD8+ T cells which are independently affected, in human later life, by age and antigen-specific responses to CMV, respectively.