Medical therapy of gliomas

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• 作者：Manmeet S. Ahluwalia ; Susan M. Chang
• 关键词：Chemotherapy ; Targeted treatment ; Gliomas ; Glioblastoma ; Clinical trial ; Molecular profile ; Multidisciplinary
• 刊名：Journal of Neuro-Oncology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：119
• 期：3
• 页码：503-512
• 全文大小：225 KB
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• 作者单位：Manmeet S. Ahluwalia (1)
  Susan M. Chang (2)
  
  1. The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA
  2. Division of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, CA, USA
  
• ISSN：1573-7373

文摘

Medical therapies are an important part of adjunctive therapy for gliomas. In this chapter we will review the chemotherapeutic and targeted agents that have been evaluated in clinical trials in grade II–IV gliomas in the last decade. A number of randomized phase III trials were completed and reported. There has been a clear success in oligodendroglial tumors and low grade glioma. Although some progress has been made in glioblastoma, considerable work involving the multidisciplinary collaboration of basic science, translational and clinical investigators needs to be done to improve the outcome of patients with anaplastic astrocytoma and glioblastoma. In addition, tailoring treatment based on molecular cytogenetic characteristics is a major focus of research into precision based medicine for glioma.