Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan

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• 作者：Dongdong Wang ; DanXu ; Yuelin Sun ; Yuanyuan Wu ; Lili Ma…
• 关键词：Low molecular chitosan ; Tanshinone I ; Anticancer ; Metastasis ; Apoptosis
• 刊名：Glycoconjugate Journal
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：1
• 页码：3-12
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biochemistry, general; Pathology;
• 出版者：Springer US
• ISSN：1573-4986
• 卷排序：34

文摘

In this study, we synthesized a novel water-soluble low molecular chitosan (LMC) derivative through Vilsmeier reaction and reductive amination reaction. The derivative was characterized by UV-visible spectroscopy, 1H NMR, FTIR and SEM techniques. The results showed that the derivative effectively reduced the cell viability rate, inhibited cell metastasis, induced cell apoptosis and dissipated mitochondrial membrane potential (ΔΨm). Moreover, the antitumor activity was strengthened with the increase of the degree of substitution of tanshinone I (TanI). These findings provided important support for developing new water-soluble antitumor agent and expand the scope of application of LMC.