| |
Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic childre
- 作者:Ling-I. Hsu ; Anand P. Chokkalingam ; Farren B. S. Briggs…
- 关键词:Cancer ; Genetic association ; Early ; life infections ; Childhood leukemia ; Gene–environment interaction
- 刊名:Cancer Causes & Control
- 出版年:2015
- 出版时间:April 2015
- 年:2015
- 卷:26
- 期:4
- 页码:609-619
- 全文大小:460 KB
- 参考文献:1. Kaatsch, P (2010) Epidemiology of childhood cancer. Cancer Treat Rev 36: pp. 277-285 CrossRef
2. Pui, CH, Relling, MV, Downing, JR (2004) Acute lymphoblastic leukemia. N Engl J Med 350: pp. 1535-1548 CrossRef 3. Eden, T (2010) Aetiology of childhood leukaemia. Cancer Treat Rev 36: pp. 286-297 CrossRef 4. Urayama, KY, Chokkalingam, AP, Manabe, A, Mizutani, S (2013) Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia. Int J Hematol 97: pp. 3-19 CrossRef 5. Vijayakrishnan, J, Houlston, RS (2010) Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Haematologica 95: pp. 1405-1414 CrossRef 6. Papaemmanuil, E, Hosking, FJ, Vijayakrishnan, J, Price, A, Olver, B, Sheridan, E (2009) Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 41: pp. 1006-1010 CrossRef 7. Orsi, L, Rudant, J, Bonaventure, A, Goujon-Bellec, S, Corda, E, Evans, TJ (2012) Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE). Leukemia 26: pp. 2561-2564 CrossRef 8. Trevino, LR, Yang, W, French, D, Hunger, SP, Carroll, WL, Devidas, M (2009) Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 41: pp. 1001-1005 CrossRef 9. Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C, et al (2013) Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst 10. Greaves, M (2006) Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer 6: pp. 193-203 CrossRef 11. Ma, X, Buffler, PA, Wiemels, JL, Selvin, S, Metayer, C, Loh, M (2005) Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomark Prev 14: pp. 1928-1934 CrossRef 12. Hochberg, Y, Benjamini, Y (1990) More powerful procedures for multiple significance testing. Stat Med 9: pp. 811-818 CrossRef 13. Urayama, KY, Buffler, PA, Gallagher, ER, Ayoob, JM, Ma, X (2010) A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia. Int J Epidemiol 39: pp. 718-732 CrossRef 14. Urayama, KY, Ma, X, Selvin, S, Metayer, C, Chokkalingam, AP, Wiemels, JL (2011) Early life exposure to infections and risk of childhood acute lymphoblastic leukemia. Int J Cancer 128: pp. 1632-1643 CrossRef 15. Westergaard, T, Andersen, PK, Pedersen, JB, Olsen, JH, Frisch, M, Sorensen, HT (1997) Birth characteristics, sibling patterns, and acute leukemia risk in childhood: a population-based cohort study. J Natl Cancer Inst 89: pp. 939-947 CrossRef 16. Dockerty, JD, Draper, G, Vincent, T, Rowan, SD, Bunch, KJ (2001) Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers. Int J Epidemiol 30: pp. 1428-1437 CrossRef 17. Roman, E, Simpson, J, Ansell, P, Kinsey, S, Mitchell, CD, McKinney, PA (2007) Childhood acute lymphoblastic leukemia and infections in the first year of life: a report from the Unit - 刊物类别:Medicine
- 刊物主题:Medicine & Public Health
Oncology Cancer Research Public Health Epidemiology Hematology
- 出版者:Springer Netherlands
- ISSN:1573-7225
文摘
Background Genome-wide association studies focusing on European-ancestry populations have identified ALL risk loci on IKZF1, ARID5B, and CEBPE. To capture the impacts of these genes on ALL risk in the California Hispanic population, we comprehensively assessed the variation within the genes and further assessed the joint effects between the genetic variation and surrogates for early-life infections (the presence of older siblings, daycare attendance, and ear infections). Methods Genotypic data for 323 Hispanic ALL cases and 454 controls from the California Childhood Leukemia Study were generated using Illumina OmniExpress v1 platform. Logistic regression assuming a log-additive model estimated odds ratios (OR) associated with each SNP, adjusted for age, sex, and the first five principal components. In addition, we examined potential interactions between six ALL risk alleles and surrogates for early-life infections using logistic regression models that included an interaction term. Results Significant associations between genotypes at IKZF1, ARID5B, and CEBPE and ALL risk were identified: rs7780012, OR 0.50, 95?% confidence interval (CI) 0.35-.71 (p?=?0.004); rs7089424, OR 2.12, 95?% CI 1.70-.65 (p?=?1.16?×?10?); rs4982731, OR 1.69, 95?% CI 1.37-.08 (p?=?2.35?×?10?), respectively. Evidence for multiplicative interactions between genetic variants and surrogates for early-life infections with ALL risk was not observed. Conclusions Consistent with findings in non-Hispanic White population, our study showed that variants within IKZF1, ARID5B, and CEBPE were associated with increased ALL risk, and the effects for ARID5B and CEBPE were most prominent in the high-hyperdiploid ALL subtype in the California Hispanic population. Results implicate the ARID5B, CEBPE, and IKZF1 genes in the pathogenesis of childhood ALL.
| |
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.
| |