Neuronal autoantibodies in epilepsy patients with peri-ictal autonomic findings

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• 作者：Leyla Baysal-Kirac ; Erdem Tuzun ; Ece Erdag ; Canan Ulusoy…
• 关键词：Autoimmune epilepsy ; Limbic encephalitis ; Autonomic seizure semiology ; NMDAR ; VGKC Ab
• 刊名：Journal of Neurology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：263
• 期：3
• 页码：455-466
• 全文大小：590 KB
• 参考文献：1.Shorvon S, Frederick A, Renzo G (2011) The causes of epilepsy: common and uncommon causes in adults and children. Cambridge University Press, CambridgeCrossRef
  2.McKnight K, Jiang Y, Hart Y, Cavey A, Wroe S, Blank M et al (2005) Serum antibodies in epilepsy and seizure-associated disorders. Neurology 65:1730–1736CrossRef PubMed
  3.Majoie HJ, de Baets M, Renier W, Lang B, Vincent A (2006) Antibodies to voltage-gated potassium and calcium channels in epilepsy. Epilepsy Res 71:135–141CrossRef PubMed
  4.Quek AM, Britton JW, McKeon A, So E, Lennon VA, Shin C et al (2012) Autoimmune epilepsy: clinical characteristics and response to immunotherapy. Arch Neurol 69:582–593CrossRef PubMed PubMedCentral
  5.Liimatainen S, Peltola M, Sabater L, Fallah M, Kharazmi E, Haapala AM et al (2010) Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy. Epilepsia 51:760–767CrossRef PubMed
  6.Brenner T, Sills GJ, Hart Y, Howell S, Waters P, Brodie MJ et al (2013) Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy. Epilepsia 54:1028–1035CrossRef PubMed
  7.Suleiman J, Wright S, Gill D, Brilot F, Waters P, Peacock K et al (2013) Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies. Epilepsia 54:2091–2100CrossRef PubMed
  8.Ekizoglu E, Tuzun E, Woodhall M, Lang B, Jacobson L, Icoz S et al (2014) Investigation of neuronal autoantibodies in two different focal epilepsy syndromes. Epilepsia 55:414–422CrossRef PubMed
  9.Irani SR, Buckley C, Vincent A, Cockerell OC, Rudge P, Johnson MR et al (2008) Immunotherapy-responsive seizure-like episodes with potassium channel antibodies. Neurology 71:1647–1648CrossRef PubMed
  10.Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, Zandi MS et al (2010) N-methyl-d -aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly nonparaneoplastic disorder of both sexes. Brain 133:1655–1667CrossRef PubMed PubMedCentral
  11.Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M et al (2008) Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091–1098CrossRef PubMed PubMedCentral
  12.Wieser S, Kelemen A, Barsi P, Vincent A, Borbely C, Rasonyi G et al (2005) Pilomotor seizures and status in non-paraneoplastic limbic encephalitis. Epileptic Disord 7:205–211PubMed
  13.Rocamora R, Becerra JL, Fossas P, Gomez M, Vivanco-Hidalgo RM, Mauri JA et al (2014) Pilomotor seizures: an autonomic semiology of limbic encephalitis? Seizure 3:670–673CrossRef
  14.Barber PA, Anderson NE, Vincent A (2000) Morvan’s syndrome associated with voltage-gated K+ channel antibodies. Neurology 54:771–772CrossRef PubMed
  15.Liguori R, Vincent A, Clover L, Avoni P, Plazzi G, Cortelli P et al (2001) Morvan’s syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain 124:2417–2426CrossRef PubMed
  16.Zuliani L, Graus F, Giometto B, Bien C, Vincent A (2012) Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition. J Neurol Neurosurg Psychiatry 83:638–645CrossRef PubMed PubMedCentral
  17.Baysal-Kirac L, Tuzun E, Altindag E, Ekizoglu E, Kinay D, Bilgic B et al (2015) Are there any specific EEG findings in autoimmune epilepsies? Clin EEG Neurosci. doi:10.​1177/​1550059415595907​ (in press) PubMed
  18.Blume WT, Luders HO, Mizrahi E, Tassinari C, van Emde Boas W, Engel J Jr (2001) Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology. Epilepsia 42:1212–1218CrossRef PubMed
  19.Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W et al (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 51:676–685CrossRef PubMed
  20.Kwan P, Arzimanoglu A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G et al (2010) Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE commission on therapeutic strategies. Epilepsia 51:1069–1077CrossRef PubMed
  21.Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L et al (2010) Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain 133:2734–2748CrossRef PubMed PubMedCentral
  22.Pettingill P, Kramer HB, Coebergh JA, Pettingill R, Maxwell S, Nibber A et al (2015) Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization. Neurology 84:1233–1241CrossRef PubMed PubMedCentral
  23.Waters P, Woodhall M, O’Connor KC, Reindl M, Lang B, Sato DK et al (2015) MOG cell-based assay detects non-MS patients with inflammatory neurologic disease. Neurol Neuroimmunol Neuroinflamm 2:e89CrossRef PubMed PubMedCentral
  24.Zandi MS, Paterson RW, Ellul MA, Jacobson L, Al-Diwani A, Jones JL et al (2015) Clinical relevance of serum antibodies to extracellular N-methyl-d -aspartate receptor epitopes. J Neurol Neurosurg Psychiatry 86:708–713CrossRef PubMed
  25.Stefan H, Pauli E, Kerling F, Schwarz A, Koebnick C (2002) Autonomic auras: left hemispheric predominance of epileptic generators of cold shivers and goose bumps? Epilepsia 43:41–45CrossRef PubMed
  26.Dove GH, Buchhalter JR, Cascino GD (2004) Acute repetitive pilomotor seizures (goose bumps) in a patient with right mesial temporal sclerosis. Clin Neurophysiol 115:2511–2513CrossRef PubMed
  27.Meo R, Bilo L, Striano S, Ruosi P, Estraneo A, Nocerino C (1995) Transient global amnesia of epileptic origin accompanied by fever. Seizure 4:311–317CrossRef PubMed
  28.Rossetti AO, Tosi C, Despland PA, Staedler C (2007) Post-ictal fever: a rare symptom of partial seizures. Eur J Neurol 14:586–590CrossRef PubMed
  29.Vincent A, Buckley C, Schott JM, Baker I, Dewar BK, Detert N et al (2004) Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 127:701–712CrossRef PubMed
  30.Thieben M, Lennon VA, Boeve BF, Aksamit AJ, Keegan M, Vernino S (2004) Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology 62:1177–1182CrossRef PubMed
  31.Parisi P, Striano P, Villa MP, Belcastro V (2013) Ictal epileptic headache: terms do matter in clinical practice! Reply to Cianchetti et al. Cephalalgia 33:426CrossRef PubMed
  32.Titulaer MJ, McCracken L, Gabilondo L, Armangué T, Glaser C, Iizuka T et al (2013) Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 12:157–165CrossRef PubMed PubMedCentral
  33.Kayser MS, Titulaer MJ, Gresa-Arribas N, Dalmau J (2013) Frequency and characteristics of isolated psychiatric episodes in anti-n-methyl-d -aspartate receptor encephalitis. JAMA Neurol 70:1133–1139CrossRef PubMed
  34.Zandi MS, Irani SR, Lang B, Waters P, Jones PB, McKenna P et al (2011) Disease-relevant autoantibodies in first episode schizophrenia. J Neurol 258:686–688CrossRef PubMed PubMedCentral
  35.Pollak TA, Nicholson TR, Mellers JD, Vincent A, David AS (2014) Epilepsy-related psychosis: a role for autoimmunity? Epilepsy Behav 36:33–38CrossRef PubMed
  36.Kuba R, Brazdil M, Rektor I (2012) Postictal psychosis and its electrophysiological correlates in invasive EEG: a case report study and literature review. Epilepsy Behav 23:426–430CrossRef PubMed
  37.Takeda Y, Inoue Y, Tottori T, Mihara T (2001) Acute psychosis during intracranial EEGmonitoring: close relationship between psychotic symptoms and discharges in amygdala. Epilepsia 42:719–724CrossRef PubMed
  38.Dalmau J, Tuzun E, Wu HY, Masjuan J, Rossi JE, Voloschin A et al (2007) Paraneoplastic anti-N-methyl-d -aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61:25–36CrossRef PubMed PubMedCentral
  39.Viaccoz Desestret V, Ducray F, Picard G, Cavillon G, Rogemond V et al (2014) Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology 82:556–563CrossRef PubMed
  40.Schmitt SE, Pargeon K, Frechette ES, Hirsch LJ, Dalmau J, Friedman D (2012) Extreme delta brush a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology 79:1094–1100CrossRef PubMed PubMedCentral
  41.Johnson N, Henry C, Fessler AJ, Dalmau J (2010) Anti-NMDA receptor encephalitis causing prolonged nonconvulsive status epilepticus. Neurology 75:1480–1482CrossRef PubMed PubMedCentral
  42.Kirkpatrick MP, Clarke CD, Sonmezturk HH, Abou-Khalil B (2011) Rhythmic delta activity represents a form of nonconvulsive status epilepticus in anti-NMDA receptor antibody encephalitis. Epilepsy Behav 20:392–394CrossRef PubMed
  43.Malter MP, Frisch C, Zeitler H, Surges R, Urbach H, Helmstaedter C et al (2015) Treatment of immune-mediated temporal lobe epilepsy with GAD antibodies. Seizure 30:57–63CrossRef PubMed
  44.Bien CG, Vincent A, Barnett MH, Becker AJ, Blümcke I, Graus F et al (2012) Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain 135:1622–1638CrossRef PubMed
  45.Errichiello L, Perruolo G, Pascarella A, Formisano P, Minetti C, Striano S et al (2009) Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: a study on 233 patients. J Neuroimmunol 211:120–123CrossRef PubMed
  
• 作者单位：Leyla Baysal-Kirac (1)
  Erdem Tuzun (2)
  Ece Erdag (2)
  Canan Ulusoy (2)
  Ebru Nur Vanli-Yavuz (1)
  Esme Ekizoglu (1)
  Sian Peach (3)
  Mine Sezgin (1)
  Nerses Bebek (1)
  Candan Gurses (1)
  Aysen Gokyigit (1)
  Angela Vincent (3)
  Betul Baykan (1)
  
  1. Department of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Capa, Fatih, Istanbul, Turkey
  2. Department of Neuroscience, Institute of Experimental Medical Research, Istanbul University, Istanbul, Turkey
  3. Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neurosciences
  Neuroradiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1459

文摘

Autonomic dysfunction has frequently been reported in autoimmune encephalitis associated with seizures and there is growing evidence that epilepsy patients may display neuronal autoantibodies (NAAb). The aim of this study was to investigate the frequency of NAAb in epilepsy patients with peri-ictal autonomic findings. Fifty-eight patients (37 women/21 men; average age of 34.2 ± 9.9 years and epilepsy duration of 19.1 ± 9.6 years) who had at least one video-EEG recorded focal or secondary generalized seizure with clear-cut documented peri-ictal autonomic findings, or consistently reported seizures with autonomic semiology, were included. NAAb were tested by RIA or cell based assays. NAAb were present in 17 of 58 (29.3 %) patients. Among seropositive patients, antibodies were directed against N-methyl-d-aspartate receptor (NMDAR) in 5 (29 %), contactin-associated protein-like 2 (CASPR2) in 5 (29 %), uncharacterized voltage gated potassium channel (VGKC)-complex antigens in 3 (18 %), glutamic acid decarboxylase (GAD) in 2 (12 %), glycine receptor (GLYR) in one (6 %) and type A gamma aminobutyric acid receptor (GABA_AR) in one patient (6 %). Peri-ictal gastrointestinal manifestations, piloerection, ictal fever, urinary urge, and cough occurred more commonly in the seropositive group. The prevalences of psychotic attacks and status epilepticus were significantly increased in the seropositive group. Seropositivity prevalence in our patient group with peri-ictal autonomic findings is higher than other previously reported epilepsy cohorts. In our study, ictal fever-VGKC-complex antibody and pilomotor seizure-GABA_AR antibody associations were documented for the first time. Chronic epilepsy patients with peri-ictal autonomic semiology, history of status epilepticus and psychotic disorder may benefit from autoantibody screening.