Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications

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• 作者：Michael J. Parnham
• 关键词：Models of inflammation ; Drug effects ; Ebselen ; Prostaglandin E ; Azithromycin ; EAE
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：1
• 页码：1-12
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

Introduction Discussion of the relevance of suitable experimental models for the effective translation of drug effects to clinical inflammatory diseases has a long history. Much emphasis is placed these days on genetically transformed mice, which may have developmental drawbacks. But are established models redundant?