Toward Quantitative Small Animal Pinhole SPECT: Assessment of Quantitation Accuracy Prior to Image Compensations

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• 作者：Chia-Lin Chen (1)
  Yuchuan Wang (2)
  Jason J. S. Lee (3)
  Benjamin M. W. Tsui (2)
  
• 关键词：Quantitation ; Pinhole SPECT ; Small animal imaging ; Image compensations ; Attenuation ; Scatter ; Image resolution
• 刊名：Molecular Imaging and Biology
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：11
• 期：3
• 页码：195-203
• 全文大小：240KB
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• 作者单位：Chia-Lin Chen (1)
  Yuchuan Wang (2)
  Jason J. S. Lee (3)
  Benjamin M. W. Tsui (2)
  
  1. Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China
  2. Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA
  3. Department of Biomedical Imaging & Radiological Sciences, National Yang-Ming University, Taipei 102, Taiwan, Republic of China
  

文摘

Purpose We assessed the quantitation accuracy of small animal pinhole single photon emission computed tomography (SPECT) under the current preclinical settings, where image compensations are not routinely applied. Procedures The effects of several common image-degrading factors and imaging parameters on quantitation accuracy were evaluated using Monte-Carlo simulation methods. Typical preclinical imaging configurations were modeled, and quantitative analyses were performed based on image reconstructions without compensating for attenuation, scatter, and limited system resolution. Results Using mouse-sized phantom studies as examples, attenuation effects alone degraded quantitation accuracy by up to ?8% (Tc-99m or In-111) or ?1% (I-125). The inclusion of scatter effects changed the above numbers to ?2% (Tc-99m or In-111) and ?1% (I-125), respectively, indicating the significance of scatter in quantitative I-125 imaging. Region-of-interest (ROI) definitions have greater impacts on regional quantitation accuracy for small sphere sources as compared to attenuation and scatter effects. For the same ROI, SPECT acquisitions using pinhole apertures of different sizes could significantly affect the outcome, whereas the use of different radii-of-rotation yielded negligible differences in quantitation accuracy for the imaging configurations simulated. Conclusions We have systematically quantified the influence of several factors affecting the quantitation accuracy of small animal pinhole SPECT. In order to consistently achieve accurate quantitation within 5% of the truth, comprehensive image compensation methods are needed.