Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight

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• 作者：Bram G. Janssen ; Wilfried Gyselaers ; Hyang-Min Byun…
• 关键词：Birth weight ; CYP1A1 ; Epigenetics ; DNA methylation ; Mitochondrial DNA content ; Mitochondrial DNA methylation ; Placental tissue ; Tobacco smoke
• 刊名：Journal of Translational Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：1668KB
• 刊物主题：Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876
• 卷排序：15

文摘

BackgroundMaternal smoking during pregnancy results in an increased risk of low birth weight through perturbations in the utero-placental exchange. Epigenetics and mitochondrial function in fetal tissues might be molecular signatures responsive to in utero tobacco smoke exposure.