Presphenoidal synchondrosis fusion in DBA/2J mice

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• 作者：Allysa Adams (1)
  Brandeis McBratney-Owen (1) (2)
  Brittany Newby (1)
  Margot E. Bowen (1) (3)
  Bjorn R. Olsen (4)
  Matthew L. Warman (1) (3) (5)
  
• 刊名：Mammalian Genome
• 出版年：2013
• 出版时间：2 - February 2013
• 年：2013
• 卷：24
• 期：1
• 页码：54-62
• 全文大小：788KB
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• 作者单位：Allysa Adams (1)
  Brandeis McBratney-Owen (1) (2)
  Brittany Newby (1)
  Margot E. Bowen (1) (3)
  Bjorn R. Olsen (4)
  Matthew L. Warman (1) (3) (5)
  
  1. Orthopaedic Research Laboratories, Boston Children鈥檚 Hospital, Boston, MA, USA
  2. University of Melbourne, Melbourne, VIC, Australia
  3. Department of Genetics, Harvard Medical School, Boston, MA, USA
  4. Harvard School of Dental Medicine, Boston, MA, USA
  5. Howard Hughes Medical Institute, Boston Children鈥檚 Hospital, Boston, MA, USA
  
• ISSN：1432-1777

文摘

Cranial base growth plates are important centers of longitudinal growth in the skull and are responsible for the proper anterior placement of the face and the stimulation of normal cranial vault development. We report that the presphenoidal synchondrosis (PSS), a midline growth plate of the cranial base, closes in the DBA/2J mouse strain but not in other common inbred strains. We investigated the genetics of PSS closure in DBA/2J mice by evaluating F1, F1 backcross, and/or F1 intercross offspring from matings with C57BL/6J and DBA/1J mice, whose PSS remain open. We observed that PSS closure is genetically determined, but not inherited as a simple Mendelian trait. Employing a genome-wide SNP array, we identified a region on chromosome 11 in the C57BL/6J strain that affected the frequency of PSS closure in F1 backcross and F1 intercross offspring. The equivalent region in the DBA/1J strain did not affect PSS closure in F1 intercross offspring. We conclude that PSS closure in the DBA/2J strain is complex and modified by different loci when outcrossed with C57BL/6J and DBA/1J mice.