Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma

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• 作者：Arezoo Rasti ; Maryam Abolhasani…
• 关键词：CXCR4 ; Cancer stem cells (CSCs) ; Renal cell carcinoma (RCC) ; Tissue microarray (TMA)
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：143
• 期：1
• 页码：95-104
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1335
• 卷排序：143

文摘

PurposeCancer stem cells (CSCs) represent a population with tumour-initiating, self-renewal, and differentiation potential. This study aimed to evaluate the expression patterns and clinical significance of chemokine receptor type 4 (CXCR4) as a novel CSC marker in renal cell carcinoma (RCC).