Exercise training improves cardiopulmonary and endothelial function in women with breast cancer: findings from the Diana-5 dietary intervention study

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• 作者：Francesco Giallauria ; Alessandra Vitelli ; Luigi Maresca…
• 关键词：Cancer ; Breast cancer ; Exercise training ; Cardiopulmonary exercise testing ; Endothelial function
• 刊名：Internal and Emergency Medicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：11
• 期：2
• 页码：183-189
• 全文大小：376 KB
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• 作者单位：Francesco Giallauria (1)
  Alessandra Vitelli (1)
  Luigi Maresca (1)
  Maria Santucci De Magistris (2)
  Paolo Chiodini (3)
  Amalia Mattiello (2)
  Marco Gentile (2)
  Maria Mancini (1)
  Alessandra Grieco (1)
  Angelo Russo (1)
  Rosa Lucci (1)
  Giorgio Torella (1)
  Franco Berrino (4)
  Salvatore Panico (2)
  Carlo Vigorito (1)
  
  1. Division of Internal Medicine and Cardiac Rehabilitation, Department of Translational Medical Sciences, University of Naples “Federico II”, Via S. Pansini 5, 80131, Naples, NA, Italy
  2. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
  3. Medical Statistics Unit, Second University of Naples, Naples, Italy
  4. Department of Preventive and Predictive Medicine, National Cancer Institute, Milan, Italy
  
• 刊物主题：Internal Medicine;
• 出版者：Springer Milan
• ISSN：1970-9366

文摘

To investigate whether exercise training (ET) improves cardiopulmonary and endothelial function in women with breast cancer (BC). Fifty-one female patients (aged between 39 and 72 years) with a history of primary invasive BC within the previous 5 years and enrolled in the Mediterranean diet-based DIANA (diet and androgens)-5 Trial were subdivided into 2 groups: an ET group (n = 25) followed a formal ET program of moderate intensity (3 session/week on a bicycle at 60–70 % VO₂peak for 3 months, followed by one session/week until 1-year follow-up), while a control group (n = 26) did not perform any formal ET. At baseline and at 1-year follow-up, all patients underwent cardiopulmonary exercise stress test (CPET) and measurements of vascular endothelial function by peripheral artery tonometry (Reactive Hyperemia Index, RHI). There were no significant differences between the groups in baseline anthropometrical, BC characteristics, and metabolic profile. No differences in baseline CPET and RHI parameters were found. Peak oxygen consumption (VO₂peak) significantly increased in ET group (from 12.4 ± 2.9 to 14.3 ± 3.3 mL/kg/min, p < 0.001) compared to the control group (from 12.8 ± 2.5 to 12.6 ± 2.8 mL/kg/min, p = 0.55; p < 0.001 between groups). Compared to the control group (from 2.0 ± 0.4 to 1.9 ± 0.4, p = 0.62), the ET group showed a significant improvement of RHI after 1 year (from 2.1 ± 0.7 to 2.5 ± 0.8, p < 0.001). Changes in VO₂peak were correlated with changes in RHI (ΔVO₂peak vs. ΔRHI: r = 0.47, p = 0.017). In BC survivors, ET program improves cardiopulmonary functional capacity and vascular endothelial function after 12 months. Whether these changes may favorably modulate some of the pathophysiological mechanisms implied in cancer evolution should be investigated.