The role of two-pore-domain background K+ (K2P) channels in the thalamus

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• 作者：Pawan Bista ; Manuela Cerina ; Petra Ehling…
• 关键词：TASK channels ; TREK channels ; Muscarinic modulation ; Thalamic firing modes ; Thalamocortical network
• 刊名：Pfl篓鹿gers Archiv - European Journal of Physiology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：467
• 期：5
• 页码：895-905
• 全文大小：883 KB
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• 作者单位：Pawan Bista (1) (3)
  Manuela Cerina (1)
  Petra Ehling (1) (2)
  Michael Leist (1)
  Hans-Christian Pape (1)
  Sven G. Meuth (2)
  Thomas Budde (1)
  
  1. Institut für Physiologie I, Westf?lische Wilhelms-Universit?t, Robert-Koch-Str. 27a, 48149, Münster, Germany
  3. Department of Anatomy and Neurobiology, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO, 63110, USA
  2. Klinik für Allgemeine Neurologie und Institut für Physiologie-Abteilung für Neuropathophysiologie, Westf?lische Wilhelms-Universit?t, Albert-Schweitzer-Campus 1, 48149, Münster, Germany
  
• 刊物主题：Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2013

文摘

The thalamocortical system is characterized by two fundamentally different activity states, namely synchronized burst firing and tonic action potential generation, which mainly occur during the behavioral states of sleep and wakefulness, respectively. The switch between the two firing modes is crucially governed by the bidirectional modulation of members of the K_2P channel family, namely tandem of P domains in a weakly inward rectifying K+ (TWIK)-related acid-sensitive K+ (TASK) and TWIK-related K+ (TREK) channels, in thalamocortical relay (TC) neurons. Several physicochemical stimuli including neurotransmitters, protons, di- and multivalent cations as well as clinically used drugs have been shown to modulate K_2P channels in these cells. With respect to modulation of these channels by G-protein-coupled receptors, PLCβ plays a unique role with both substrate breakdown and product synthesis exerting important functions. While the degradation of PIP₂ leads to the closure of TREK channels, the production of DAG induces the inhibition of TASK channels. Therefore, TASK and TREK channels were found to be central elements in the control of thalamic activity modes. Since research has yet focused on identifying the muscarinic pathway underling the modulation of TASK and TREK channels in TC neurons, future studies should address other thalamic cell types and members of the K_2P channel family.