Comparison of chemical profiles and effectiveness between Erxian decoction and mixtures of decoctions of its individual herbs: a novel approach for identification of the standard chemicals

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• 作者：H. P. Cheung ; S. W. Wang ; T. B. Ng ; Y. B. Zhang ; L. X. Lao ; Z. J. Zhang…
• 关键词：Standard chemicals ; Chinese medicine formula ; Erxian decoction ; Menopause ; Novel approach
• 刊名：Chinese Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：1479KB
• 刊物主题：Complementary & Alternative Medicine; Traditional Chinese Medicine; Acupuncture;
• 出版者：BioMed Central
• ISSN：1749-8546
• 卷排序：12

文摘

BackgroundIdentification of bioactive standard chemicals is a major challenge in the study of the Chinese medicinal formula. In particular, the chemical components may interact differently depending on the preparative methods, therefore affecting the amounts of bioactive components and their pharmacological properties in the medicinal formula. With the use of Erxian decoction (EXD) as a study model—a  well-known Chinese medicinal formula for treating menopausal symptoms, a novel and rapid approach in seeking standard chemicals has been established by differentially comparing the HPLC profiles and the menopause-related biochemical parameters of combined decoction of EXD (EXD-C) and mixtures of the decoctions of its individual herbs (EXD-S).