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Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin
- 作者:Chen-Hsi Hsieh (1) (2) (3)
Mei-Ling Hou (2) Meng-Hsuan Chiang (2) Hung-Chi Tai (4) Hui-Ju Tien (1) Li-Ying Wang (7) Tung-Hu Tsai (2) (6) Yu-Jen Chen (2) (4) (5)
- 关键词:5 ; Fluorouracil (5 ; FU) ; Cisplatin (CDDP) ; Concurrent chemoradiation therapy (CCRT) ; Head and neck ; Pharmacokinetics ; Radiotherapy
- 刊名:Journal of Translational Medicine
- 出版年:2013
- 出版时间:December 2013
- 年:2013
- 卷:11
- 期:1
- 全文大小:693 KB
- 参考文献:1. Adelstein DJ, Lavertu P, Saxton JP, Secic M, Wood BG, Wanamaker JR, Eliachar I, Strome M, Larto MA: Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. / Cancer 2000, 88:876-83. CrossRef
2. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, / et al.: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. / N Engl J Med 2004, 350:1945-952. CrossRef 3. Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, / et al.: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. / N Engl J Med 2004, 350:1937-944. CrossRef 4. Andreadis C, Vahtsevanos K, Sidiras T, Thomaidis I, Antoniadis K, Mouratidou D: 5-Fluorouracil and cisplatin in the treatment of advanced oral cancer. / Oral Oncol 2003, 39:380-85. CrossRef 5. Amrein PC, Weitzman SA: Treatment of squamous-cell carcinoma of the head and neck with cisplatin and 5-fluorouracil. / J Clin Oncol 1985, 3:1632-639. 6. Kish JA, Ensley JF, Jacobs J, Weaver A, Cummings G, Al-Sarraf M: A randomized trial of cisplatin (CACP)---fluorouracil (5-FU) infusion and CACP---FU bolus for recurrent and advanced squamous cell carcinoma of the head and neck. / Cancer 1985, 56:2740-744. CrossRef 7. Verhey LJ: Comparison of three-dimensional conformal radiation therapy and intensity-modulated radiation therapy systems. / Semin Radiat Oncol 1999, 9:78-8. CrossRef 8. Shueng PW, Lin SC, Chong NS, Lee HY, Tien HJ, Wu LJ, Chen CA, Lee JJ, Hsieh CH: Total marrow irradiation with helical tomotherapy for bone marrow transplantation of multiple myeloma: first experience in Asia. / Technol Cancer Res Treat 2009, 8:29-8. 9. Chao KS, Low DA, Perez CA, Purdy JA: Intensity-modulated radiation therapy in head and neck cancers: The Mallinckrodt experience. / Int J Cancer 2000, 90:92-03. CrossRef 10. Tai HC, Hsieh CH, Chao KS, Liu SH, Leu YS, Chang YF, Hsiao HT, Chang YC, Huang DY, Chen YJ: Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction. / Acta Otolaryngol 2009, 129:311-17. CrossRef 11. Shueng PW, Shen BJ, Wu LJ, Liao LJ, Hsiao CH, Lin YC, Cheng PW, Lo WC, Jen YM, Hsieh CH: Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma. / Radiat Oncol 2011, 6:95. CrossRef 12. Shueng PW, Lin SC, Chang HT, Chong NS, Chen YJ, Wang LY, Hsieh YP, Hsieh CH: Toxicity risk of non-target organs at risk receiving low-dose radiation: case report. / Radiat Oncol 2009, 4:71. CrossRef 13. Hsieh CH, Chang HT, Lin SC, Chen YJ, Wang LY, Hsieh YP, Chen CA, Chong NS, Lin SL, Chen CY, / et al.: Toxic risk of stereotactic body radiotherapy and concurrent helical tomotherapy followed by erlotinib for non-small-cell lung cancer treatment–case report. / BMC Cancer 2010, 10:696. CrossRef 14. Morgan WF: Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. / Radiat Res 2003, 159:567-80. CrossRef 15. Mothersill C, Seymour CB: Radiation-induced bystander effects–implications for cancer. / Nat Rev Cancer 2004, 4:158-64. CrossRef 16. Kaminski JM, Shinohara E, Summers JB, Niermann KJ, Morimoto A, Brousal J: The controversial abscopal effect. / Cancer Treat Rev 2005, 31:159-72. CrossRef 17. Hsieh CH, Hsieh YJ, Liu CY, Tai HC, Huang YC, Shueng PW, Wu LJ, Wang LY, Tsai TH, Chen YJ: Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics. / J Transl Med 2010, 8:29. CrossRef 18. Hsieh CH, Liu CY, Hsieh YJ, Tai HC, Wang LY, Tsai TH, Chen YJ: Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil. / PLoS ONE 2011, 6:e21000. CrossRef 19. Hirata K, Horie T: A prostaglandin E1 analog, OP-1206, alleviates 5-fluorouracil-induced injury of rat small intestine. / Res Commun Mol Pathol Pharmacol 1999, 104:243-51. 20. Yuasa H, Matsuhisa E, Watanabe J: Intestinal brush border transport mechanism of 5-fluorouracil in rats. / Biol Pharm Bull 1996, 19:94-9. CrossRef 21. Marcu L, van Doorn T, Olver I: Cisplatin and radiotherapy in the treatment of locally advanced head and neck cancer–a review of their cooperation. / Acta Oncol 2003, 42:315-25. CrossRef 22. Dewit L: Combined treatment of radiation and cisdiamminedichloroplatinum (II): a review of experimental and clinical data. / Int J Radiat Oncol Biol Phys 1987, 13:403-26. CrossRef 23. Coughlin CT, Richmond RC: Biologic and clinical developments of cisplatin combined with radiation: concepts, utility, projections for new trials, and the emergence of carboplatin. / Semin Oncol 1989, 16:31-3. 24. Sorenson CM, Barry MA, Eastman A: Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. / J Natl Cancer Inst 1990, 82:749-55. CrossRef 25. Sorenson CM, Eastman A: Mechanism of cis-diamminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks. / Cancer Res 1988, 48:4484-488. 26. Sorenson CM, Eastman A: Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells. / Cancer Res 1988, 48:6703-707. 27. Pawlik TM, Keyomarsi K: Role of cell cycle in mediating sensitivity to radiotherapy. / Int J Radiat Oncol Biol Phys 2004, 59:928-42. CrossRef 28. Yoshikawa A, Saura R, Matsubara T, Mizuno K: A mechanism of cisplatin action: antineoplastic effect through inhibition of neovascularization. / Kobe J Med Sci 1997, 43:109-20. 29. Jarugula VR, Lam SS, Boudinot FD: Nonlinear pharmacokinetics of 5-fluorouracil in rats. / J Pharm Sci 1997, 86:756-58. CrossRef 30. Prajda N, Kralovanszky J, Gal F, Kiss F, Kerpel-Fronius S: Evaluation of side effects of platinum complexes (CDDP, CBDCA, CHIP) on rat bone marrow. / In Vivo 1989, 3:267-70. 31. Hsieh CH, Kuo YS, Liao LJ, Hu KY, Lin SC, Wu LJ, Lin YC, Chen YJ, Wang LY, Hsieh YP, / et al.: Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. / BMC Cancer 2011, 11:37. CrossRef 32. Hsieh CH, Wei MC, Lee HY, Hsiao SM, Chen CA, Wang LY, Hsieh YP, Tsai TH, Chen YJ, Shueng PW: Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomothearapy. / Radiat Oncol 2009, 4:62. CrossRef 33. Shueng PW, Wu LJ, Chen SY, Hsiao CH, Tien HJ, Cheng PW, Kuo YS, Chen YJ, Chen CA, Hsieh PY, / et al.: Concurrent chemoradiotherapy with helical tomotherapy for oropharyngeal cancer: a preliminary result. / Int J Radiat Oncol Biol Phys 2010, 77:715-21. CrossRef 34. Bocci G, Danesi R, Di Paolo AD, Innocenti F, Allegrini G, Falcone A, Melosi A, Battistoni M, Barsanti G, Conte PF, / et al.: Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and reduced test dose in cancer patients. / Clin Cancer Res 2000, 6:3032-037. 35. Casale F, Canaparo R, Serpe L, Muntoni E, Pepa CD, Costa M, Mairone L, Zara GP, Fornari G, Eandi M: Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients. / Pharmacol Res 2004, 50:173-79. CrossRef 36. Peters GJ: Antimetabolites. In / Oxford textbook of oncology. Edited by: Peckam M, Pinedo HM, Veronesi U. London: Oxford University Press; 1995:524-52. 37. Owen CA, Hu Z, Lopez-Otin C, Shapiro SD: Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. / J Immunol 2004, 172:7791-803. 38. Balbin M, Fueyo A, Knauper V, Pendas AM, Lopez JM, Jimenez MG, Murphy G, Lopez-Otin C: Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus. / J Biol Chem 1998, 273:23959-3968. CrossRef 39. Yuasa H, Matsuda K, Gu J, Suzuki E, Yokouchi I, Watanabe J: Dose-dependent gastrointestinal absorption of 5-fluorouracil in rats in vivo. / Biol Pharm Bull 1996, 19:1494-498. CrossRef 40. Kuwahara D, Tsutsumi K, Kobayashi T, Hasunuma T, Nishioka K: Caspase-9 regulates cisplatin-induced apoptosis in human head and neck squamous cell carcinoma cells. / Cancer Lett 2000, 148:65-1. CrossRef 41. Ohtani T, Hatori M, Ito H, Takizawa K, Kamijo R, Nagumo M: Involvement of caspases in 5-FU induced apoptosis in an oral cancer cell line. / Anticancer Res 2000, 20:3117-121. 42. Drewinko B, Brown BW, Gottlieb JA: The effect of cis-diamminedichloroplatinum (II) on cultured human lymphoma cells and its therapeutic implications. / Cancer Res 1973, 33:3091-095. 43. Zwelling LA, Kohn KW: Mechanism of action of cis-dichlorodiammineplatinum(II). / Cancer Treat Rep 1979, 63:1439-444. 44. Okamura M, Kobayashi M, Suzuki F, Shimada J, Sakagami H: Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line. / Anticancer Res 2007, 27:3331-337. 45. Spiegelman S, Sawyer R, Nayak R, Ritzi E, Stolfi R, Martin D: Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation. / Proc Natl Acad Sci USA 1980, 77:4966-970. CrossRef 46. Parker WB, Cheng YC: Metabolism and mechanism of action of 5-fluorouracil. / Pharmacol Ther 1990, 48:381-95. CrossRef 47. Li MH, Ito D, Sanada M, Odani T, Hatori M, Iwase M, Nagumo M: Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines. / Oral Oncol 2004, 40:63-0. CrossRef 48. Bosset JF, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, Bardet E, Beny A, Ollier JC: Chemotherapy with preoperative radiotherapy in rectal cancer. / N Engl J Med 2006, 355:1114-123. CrossRef 49. Eifel PJ, Winter K, Morris M, Levenback C, Grigsby PW, Cooper J, Rotman M, Gershenson D, Mutch DG: Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-1. / J Clin Oncol 2004, 22:872-80. CrossRef
- 作者单位:Chen-Hsi Hsieh (1) (2) (3)
Mei-Ling Hou (2) Meng-Hsuan Chiang (2) Hung-Chi Tai (4) Hui-Ju Tien (1) Li-Ying Wang (7) Tung-Hu Tsai (2) (6) Yu-Jen Chen (2) (4) (5)
1. Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, Taipei, Taiwan 2. Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 155, Li-Nong Street Section 2, Taipei, 112, Taiwan 3. Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan 4. Department of Radiation Oncology, Mackay Memorial Hospital, 92, Chung-Shan North Road, Taipei, Taiwan 7. School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan 6. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan 5. Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
- ISSN:1479-5876
文摘
Background 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU and CDDP in rats as experimental model. Methods The radiation dose distributions of HN cancer patients were determined for the low dose areas, which are generously deposited around the target volume. Two Gy and 0.5?Gy RT were selected. Single-fraction radiation was delivered to the HN of Sprague–Dawley rats. 5-FU at 100?mg/kg or CDDP at 5?mg/kg was intravenously infused 24?hours after radiation. Results Radiation at 2?Gy reduced the area under the plasma concentration vs. time curve (AUC) of 5-FU and CDDP by 16% and 29% compared to non-irradiated controls, respectively. This was accompanied by incremental total plasma clearance values. Intriguingly, low dose radiation at 0.5?Gy resulted in a similar pharmacokinetic profile, with a 17% and 33% reduction in the AUC of 5-FU and CDDP, respectively. The changes in AUC of bile, which increases with RT, were opposite to AUC of plasma for both drugs. Conclusions The local HN RT could modulate systemic PK of 5-FU and CDDP in rats. This unexpected RT-PK phenomena may provide a reference for adjustment of drug administration and is worthy of further investigation. Trial registration ClinicalTrials.gov ID NCT01755585 and NCT01609114
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