Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney

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• 作者：L. Pelligand ; N. Suemanotham ; J. N. King ; W. Seewald ; H. Syme…
• 关键词：Furosemide ; Cyclooxygenase ; COXib ; NSAIDs ; Robenacoxib ; Ketoprofen ; Feline ; Renal ; Macula densa ; Renin ; angiotensin ; aldosterone system
• 刊名：BMC Veterinary Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：11
• 期：1
• 全文大小：2,067 KB
• 刊物主题：Veterinary Medicine; Zoology; Transgenics;
• 出版者：BioMed Central
• ISSN：1746-6148

文摘

Background The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal anti-inflammatory drugs (NSAIDs) with differing selectivity profiles: robenacoxib (COX-2 selective) and ketoprofen (COX-1 selective).