PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors

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• 作者：Wei Wang ; Xiao-Wen Song ; Xian-Min Bu ; Ning Zhang ; Cheng-Hai Zhao
• 关键词：PDCD2 ; NCoR1 ; GIST ; Survival rate ; Smad
• 刊名：Cellular Oncology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：39
• 期：2
• 页码：129-137
• 全文大小：706 KB
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• 作者单位：Wei Wang (1)
  Xiao-Wen Song (1)
  Xian-Min Bu (2)
  Ning Zhang (1)
  Cheng-Hai Zhao (1)
  
  1. Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, People’s Republic of China
  2. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China
  
• 刊物主题：Cancer Research; Biomedicine general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436

文摘

Purpose Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Previously, PDCD2 (programmed cell death protein 2) has been identified as a putative tumor suppressor in gastric cancer. As yet, however, no reports on PDCD2 expression and its physical interactor NCoR1 (nuclear receptor co-repressor), and their effects in GIST have been reported.