Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

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• 作者：Xiangxiang Zhou ; Xiaosheng Fang ; Yujie Jiang…
• 关键词：Diffuse large B cell lymphoma ; Klotho ; Insulin growth factor ; 1 receptor ; Tumor suppressor
• 刊名：Journal of Hematology & Oncology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：5906KB
• 刊物主题：Oncology; Hematology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-8722
• 卷排序：10

文摘

BackgroundKlotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways. These pathways are involved in the development and progression of B cell lymphoma. We aimed to explore the expression pattern and functional mechanism of Klotho in diffuse large B cell lymphoma (DLBCL).