Primitive neuroectodermal tumor/Ewing’s sarcoma with long-term follow-up

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• 作者：Mitsuhiro Fukushima MD (1)
  Kiyoshi Koizumi MD (1)
  Yuki Nakajima MD (1)
  Yuh Fukuda MD (2)
  Masashi Kawamoto MD (2)
  Kazuo Shimizu MD (1)
  
• 关键词：primitive neuroectodermal tumor ; Askin’s tumor ; thoracic wall tumor ; malignant small round cell tumor ; extraskeletal Ewing’s sarcoma
• 刊名：General Thoracic and Cardiovascular Surgery
• 出版年：2005
• 出版时间：February 2005
• 年：2005
• 卷：53
• 期：2
• 页码：97-101
• 全文大小：1027KB
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  6. O’Sullivan MJ, Perlman EJ, Furman J, Humphrey PA, Dehner LP, Pfeifer JD. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Hum Pathol 2001; 32: 1109-5. CrossRef
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  8. Paulussen M, Ahrens S, Lehnert M, Taeger D, Hense HW, Wagner A, et al. Second malignancies after Ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. Ann Oncol 2001; 12: 1619-0. CrossRef
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  10. Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348: 694-01. CrossRef
  
• 作者单位：Mitsuhiro Fukushima MD (1)
  Kiyoshi Koizumi MD (1)
  Yuki Nakajima MD (1)
  Yuh Fukuda MD (2)
  Masashi Kawamoto MD (2)
  Kazuo Shimizu MD (1)
  
  1. Department of Surgery II, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan
  2. Department of Pathology, Nippon Medical School, Tokyo, Japan
  

文摘

We have reported a case of primitive neuroectodermal tumor/Ewing’s sarcoma (PNET/EWS) in a 32-year-old female who had had no symptoms until the tumor was detected in a general examination after she gave birth. Chest X-ray showed a well-defined, rounded mass in the left lower lung field. Computed tomographic scan of the chest revealed a distinct mass adjacent to the anterolateral thoracic wall. The macroscopic findings had shown a well-capsulated tumor with a stalk emanating from the thoracic wall. PNET/EWS was histologically diagnosed. The tumor was composed of atypical, small round cells. It stained positively with antibodies to the MIC2 gene product. Postoperative adjuvant radiotherapy of 50 Gy was performed. Adjuvant chemotherapies were not performed. Four years later, a small recurrent nodule in the left lung was surgically resected. Since her initial diagnosis, the patient has survived for seven years; in the three years since her second surgery, she has had no other recurrence or metastasis.