Synthesis and basic evaluation of 7α-(3-[¹⁸F]fluoropropyl)-testosterone and 7α-(3-[¹⁸F]fluoropropyl)-dihydrotestosterone

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• 作者：Mayumi Okamoto ; Kyosuke Naka ; Kiichi Ishiwata ; Isao Shimizu…
• 关键词：Androgen receptor ; 7α ; (3 ; [18F]Fluoropropyl) ; testosterone ; 7α ; (3 ; [18F]Fluoropropyl) ; dihydrotestosterone ; Positron emission tomography
• 刊名：Annals of Nuclear Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：53-62
• 全文大小：
• 刊物主题：Nuclear Medicine; Imaging / Radiology;
• 出版者：Springer Japan
• ISSN：1864-6433
• 卷排序：31

文摘

Objective7α-Substituted androgen derivatives may have the potential to visualize androgen receptors with positron emission tomography. In the present study, we synthesized fluoropropyl derivatives of 7α-(3-[18F]fluoropropyl)-testosterone ([18F]7) and 7α-(3-[18F]fluoropropyl)-dihydrotestosterone ([18F]15), and characterized their in vitro binding, in vivo biodistribution, and performed blocking studies in mature androgen deprived male rats.