Coronary microvascular function and myocardial fibrosis in women with angina pectoris and no obstructive coronary artery disease: the iPOWER study

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• 作者：Naja Dam Mygind ; Marie Mide Michelsen…
• 关键词：Microvascular dysfunction ; Women ; Angina pectoris ; T1 mapping ; Coronary flow velocity reserve ; Cardiovascular magnetic resonance ; Doppler echocardiography ; Positron emission tomography ; Diffuse fibrosis ; Extracellular volume
• 刊名：Journal of Cardiovascular Magnetic Resonance
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：2,398 KB
• 刊物主题：Imaging / Radiology; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1532-429X
• 卷排序：18

文摘

BackgroundEven in absence of obstructive coronary artery disease women with angina pectoris have a poor prognosis possibly due to coronary microvascular disease. Coronary microvascular disease can be assessed by transthoracic Doppler echocardiography measuring coronary flow velocity reserve (CFVR) and by positron emission tomography measuring myocardial blood flow reserve (MBFR). Diffuse myocardial fibrosis can be assessed by cardiovascular magnetic resonance (CMR) T1 mapping. We hypothesized that coronary microvascular disease is associated with diffuse myocardial fibrosis.