Bending Tau into Shape: The Emerging Role of Peptidyl-Prolyl Isomerases in Tauopathies

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• 作者：John Koren III (1)
  Umesh K. Jinwal (1)
  Zachary Davey (1)
  Janine Kiray (1)
  Karthik Arulselvam (1)
  Chad A. Dickey (1) (2)
  
• 关键词：Isomerase ; Tau ; Folding ; Phosphorylation ; Alzheimer's ; Tauopathies
• 刊名：Molecular Neurobiology
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：44
• 期：1
• 页码：65-70
• 全文大小：184KB
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• 作者单位：John Koren III (1)
  Umesh K. Jinwal (1)
  Zachary Davey (1)
  Janine Kiray (1)
  Karthik Arulselvam (1)
  Chad A. Dickey (1) (2)
  
  1. Department of Molecular Medicine, USF Health Byrd Alzheimer’s Institute, Tampa, FL, 33613, USA
  2. Departments of Molecular Medicine and Psychiatry, University of South Florida Alzheimer’s Institute, 4001 E. Fletcher Avenue MDC 36, Tampa, FL, 33618, USA
  

文摘

The Hsp90-associated cis-trans peptidyl-prolyl isomerase—FK506 binding protein 51 (FKBP51)—was recently found to co-localize with the microtubule (MT)-associated protein tau in neurons and physically interact with tau in brain tissues from humans who died from Alzheimer’s disease (AD). Tau pathologically aggregates in neurons, a process that is closely linked with cognitive deficits in AD. Tau typically functions to stabilize and bundle MTs. Cellular events like calcium influx destabilize MTs, disengaging tau. This excess tau should be degraded, but sometimes it is stabilized and forms higher-order aggregates, a pathogenic hallmark of tauopathies. FKBP51 was also found to increase in forebrain neurons with age, further supporting a novel role for FKBP51 in tau processing. This, combined with compelling evidence that the prolyl isomerase Pin1 regulates tau stability and phosphorylation dynamics, suggests an emerging role for isomerization in tau pathogenesis.