Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue

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• 作者：Johan M. Lorenzen ; Stefan ¨¹ckert ; Friedemann Scheller ; Hermann Haller and Markus A. Kuczyk
• 关键词：Human penile erectile tissue ; Arginase inhibitors ; Relaxation responses ; Cyclic GMP
• 刊名：World Journal of Urology
• 出版年：2009
• 出版时间：December, 2009
• 年：2009
• 卷：27
• 期：6
• 页码：805-810
• 全文大小：287.4 KB

文摘

Objectives An impairment in the local availability of nitric oxide (NO) may impair male erectile function. The activity of l-arginine-degrading arginase enzymes may attenuate the relaxation of cavernous smooth muscle by reducing local NO production. Arginase enzymes compete with the nitric oxide synthases for the common substrate, the amino acid l-arginine. Very little data are available regarding the significance of arginase enzymes in the control of human penile erectile tissue. The aim of the present study was to elucidate the effects of drugs known to inhibit arginase activity on the relaxation of isolated human corpus cavernosum (HCC) and the production of cyclic GMP.