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Key emerging issues in frontotemporal dementia
- 作者：Sarah A. A. Hopkins ; Dennis Chan
- 关键词：Frontotemporal dementia ; Diagnostic criteria ; Cognition ; Biomarkers ; Genetics
- 刊名：Journal of Neurology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：263
- 期：2
- 页码：407-413
- 全文大小：580 KB
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- 作者单位：Sarah A. A. Hopkins (1)
Dennis Chan (2)
1. Department of Medicine for the Elderly, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
2. Department of Clinical Neurosciences, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, UK
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Neurology
Neurosciences
Neuroradiology
- 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1459
文摘
Frontotemporal dementia (FTD) encompasses the syndromes of behavioural variant FTD (bvFTD) and primary progressive aphasia (PPA) and refers to those neurodegenerative diseases characterised by predominant pathological involvement of the frontal and temporal lobes. Recent years have witnessed major advances in the clinical characterisation of FTD, reflected in the publication of updated diagnostic criteria for bvFTD and PPA, and the discovery of new pathogenic mutations has added to the understanding of genotype–phenotype interactions and of disease mechanisms. Emerging results from longitudinal studies of familial FTD show that imaging and cognitive changes occur years before symptom onset and such studies may yield biomarkers of early disease that in turn will facilitate earlier diagnosis. The hope and (guarded) expectation is that these advances may together herald the beginning of the end of the chapter in which FTD is considered an inexorably progressive and untreatable condition. Keywords Frontotemporal dementia Diagnostic criteria Cognition Biomarkers Genetics
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