Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells

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• 作者：Khalid AlZahrani…
• 关键词：Erythrocytes ; Gamma radiation ; Nanostructure ; Atomic force microscopy
• 刊名：Indian Journal of Hematology and Blood Transfusion
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：33
• 期：1
• 页码：109-115
• 全文大小：
• 刊物主题：Hematology; Oncology; Blood Transfusion Medicine; Human Genetics;
• 出版者：Springer India
• ISSN：0974-0449
• 卷排序：33

文摘

The effect of gamma radiation on the ultrastructure of the cell membranes of red blood cells has been probed using a powerful tool, namely, atomic force microscopy. We used mice erythrocytes as a model. Blood samples withdrawn from mice were gamma-irradiated using a 60Co source unit with doses of 10,15,20,25 and 30 Gy. Structural changes appeared in the form of nanoscale potholes, depressions and alterations of the cell membrane roughness. The roughness of the cell membrane increased dramatically with increasing doses, although at 10 Gy, the cell membrane roughness was less than that of normal red blood cells (controls). Therefore, such modifications at the nano-scale level may affect the biophysical properties of membranes, resulting in impairment of their function.