Association between multiple sclerosis and epilepsy: large population-based record-linkage studies

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• 作者：Alexander N Allen (1)
  Olena O Seminog (2)
  Michael J Goldacre (2)
  
• 关键词：Epilepsy ; Multiple sclerosis ; Risk ; Coexistence ; Record ; linkage ; Epidemiology
• 刊名：BMC Neurology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：166 KB
• 参考文献：1. Wallace H, Shorvon S, Tallis R: Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2 052 922 and age-specific fertility rates of women with epilepsy. / Lancet 1998, 352:1970-973. CrossRef
  2. Ghezzi A, Montanini R, Basso PF, Zaffaroni M, Massimo E, Cazzullo CL: Epilepsy in multiple sclerosis. / Eur J Neurol 1990, 30:218-23. CrossRef
  3. Engelsen BA, Gr?nning M: Epileptic seizures in patients with multiple sclerosis: Is the prognosis of epilepsy underestimated? / Seizure 1997, 6:377-82. CrossRef
  4. Moreau T, Sochurkova D, Lemesle M, / et al.: Epilepsy in patients with multiple sclerosis: radiological-clinical correlations. / Epilepsia 1998, 39:893-96. j.1528-1157.1998.tb01187.x" target="_blank" title="It opens in new window">CrossRef
  5. Olafsson E, Benedikz J, Hauser WA: Risk of epilepsy in patients with multiple sclerosis: a population-based study in Iceland. / Epilepsia 1999, 40:745-47. j.1528-1157.1999.tb00772.x" target="_blank" title="It opens in new window">CrossRef
  6. Nicoletti, / et al.: Epilepsy and Multiple Sclerosis in Sicily: A Population-based Study. / Epilepsia 2003,44(11):1445-448. j.1528-1157.2003.09203.x" target="_blank" title="It opens in new window">CrossRef
  7. Goldacre MJ, Kurina LM, Wotton CJ, Yeates D, Seagroat V: Schizophrenia and cancer: an epidemiological study. / Br J Psychiatry 2005, 187:334-38. jp.187.4.334" target="_blank" title="It opens in new window">CrossRef
  8. Ramagopalan SV, Wotton CJ, Handel AE, Yeates D, Goldacre MJ: Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study. / BMC Med 2011, 9:1. CrossRef
  9. Breslow NE, Day NE: The design and analysis of cohort studies. In / Statistical methods in cancer research, volume II. IARC Scientific Publication No 82. Lyon: International Agency for Research in Cancer; 1987. 93-5 and 103-05
  10. Cendrowski W, Majkowski J: Epilepsy in multiple sclerosis. / J Neurol Sci 1972, 17:389-98. CrossRef
  11. Poser C, Brinar : Epilepsy and multiple sclerosis. / Epilepsy Behav 2003, 4:6-2. CrossRef
  12. Kinnunen E, Wikstrom J: Prevalence and prognosis of epilepsy in patients with multiple sclerosis. / Epilepsia 1986, 122:17-6.
  13. Lebrun C: Epilepsy and multiple sclerosis. / Epileptic Disord 2006, 8:55-8.
  14. Calabrese M, De Stefano N, Atzori M, / et al.: Extensive cortical inflammation is associated with epilepsy in multiple sclerosis. / J Neurol Neurosurg Psychiatry 2008, 255:581-86.
  15. Calabrese M, Grossi P, Favaretto A, / et al.: Cortical pathology in multiple sclerosis patients with epilepsy: a 3?year longitudinal study. / J Neurol Neurosurg Psychiatry 2012, 83:49-4. jnnp-2011-300414" target="_blank" title="It opens in new window">CrossRef
  16. Waxman SG, Dib-Hajj S, Cummins TR, Black JA: Sodium channels and their genes: dynamic expression in the normal nervous system, dysregulation in disease state (1). / Brain Res 2000, 886:5-4. CrossRef
  17. Catenoix H, Marignier R, Ritleng C, / et al.: Multiple sclerosis and epileptic seizures. / Mult Scler 2011, 17:96-02. CrossRef
  18. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/13/189/prepub
  
• 作者单位：Alexander N Allen (1)
  Olena O Seminog (2)
  Michael J Goldacre (2)
  
  1. Brasenose College, University of Oxford, Radcliffe Square, Oxford, OX1 4AJ, UK
  2. Unit of Health–Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Old Road, Oxford, OX3 7LF, UK
  
• ISSN：1471-2377

文摘

Background Multiple sclerosis (MS) and epilepsy are both fairly common and it follows that they may sometimes occur together in the same people by chance. We sought to determine whether hospitalisation for MS and hospitalisation for epilepsy occur together more often than expected by chance alone. Methods We analysed two datasets of linked statistical hospital admission records covering the Oxford Record Linkage Study area (ORLS, 1963-998) and all England (1999-011). In each, we calculated the rate of occurrence of hospital admission for epilepsy in people after admission for MS, compared with equivalent rates in a control cohort, and expressed the results as a relative risk (RR). Results The RR for hospital admission for epilepsy following an admission for MS was significantly high at 4.1 (95% confidence interval 3.1-.3) in the ORLS and 3.3 (95% CI 3.1-.4) in the all-England cohort. The RR for a first recorded admission for epilepsy 10?years and more after first recorded admission for MS was 4.7 (2.8-.3) in ORLS and 3.9 (3.1-.9) in the national cohort. The RR for the converse–MS following hospitalisation for epilepsy–was 2.5 (95% CI 1.7-.5) in the ORLS and 1.9 (95% CI 1.8-.1) in the English dataset. Conclusions MS and epilepsy occur together more commonly than by chance. One possible explanation is that an MS lesion acts as a focus of an epileptic seizure; but other possibilities are discussed. Clinicians should be aware of the risk of epilepsy in people with MS. The findings may also suggest clues for researchers in developing hypotheses about underlying mechanisms for the two conditions.