Highly efficient solvent-free synthesis of pyranopyrazoles by a Br?nsted-acidic ionic liquid as a green and reusable catalyst

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• 作者：JAVAD EBRAHIMI (1) javad_ebrahimi@ymail.com
  ALI MOHAMMADI (2) a.mohammdy62@yahoo.com
  VAHID PAKJOO (3)
  EHSAN BAHRAMZADE (3)
  AMIR HABIBI (3)
• 关键词：Pyranopyrazoles – solvent ; free synthesis – multicomponent reaction – ionic liquid – heterogeneous catalysts
• 刊名：Journal of Chemical Sciences
• 出版年：2012
• 出版时间：September 2012
• 年：2012
• 卷：124
• 期：5
• 页码：1013-1017
• 全文大小：147.9 KB
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• 作者单位：1. Young Researchers Club, Islamic Azad University, Mashhad Branch, P.O. Box 9187147578, Mashhad, Iran2. Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, P.O. Box 91775, Mashhad, Iran3. Department of Chemistry, Islamic Azad University, Mashhad Branch, P.O. Box 9187147578, Mashhad, Iran
• ISSN：0973-7103

文摘

A simple, green and efficient protocol for synthesis of dihydropyrano[2,3-c]pyrazole derivatives is developed by a four component reaction of various benzaldehydes, ethyl acetoacetate, hydrazine hydrate and malononitrile in the presence of 3-methyl-1-(4-sulphonic acid)butylimidazolium hydrogen sulphate [(CH₂)₄SO₃HMIM][HSO₄], an acidic ionic liquid and as a catalyst, under solvent-free conditions. The key advantages of this process are high yields, shorter reaction times, easy work-up, purification of products by non-chromatographic method and the reusability of the catalyst.