α-synuclein interacts with SOD1 and promotes its oligomerization

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• 作者：Anika M. Helferich ; Wolfgang P. Ruf ; Veselin Grozdanov…
• 关键词：Alpha synuclein ; SNCA ; SOD1 ; ALS ; Parkinson’s disease ; Cross ; seeding ; Oligomers
• 刊名：Molecular Neurodegeneration
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：3,453 KB
• 刊物主题：Neurosciences; Neurology; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1750-1326

文摘

Background Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are both neurodegenerative diseases leading to impaired execution of movement. α-Synuclein plays a central role in the pathogenesis of PD whereas Cu, Zn superoxide dismutase (SOD1) is a key player in a subset of familial ALS cases. Under pathological conditions both α-synuclein and SOD1 form oligomers and fibrils. In this study we investigated the possible molecular interaction of α-synuclein and SOD1 and its functional and pathological relevance.