Is correction for age necessary in neuroimaging studies of the central serotonin transporter?

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• 作者：Swen Hesse ; Henryk Barthel ; Toshiya Murai ; Ulrich Müller ; Dominic Müller ; Anita Seese ; Regine Kluge and Osama Sabri
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2003
• 出版时间：March 2003
• 年：2003
• 卷：30
• 期：3
• 页码：427-430
• 全文大小：214 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nuclear Medicine
  Imaging and Radiology
  Orthopedics
  Cardiology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1619-7089

文摘

The central neurotransmitter serotonin plays a major role in a number of neuropsychiatric disorders. However, results from post-mortem and in vivo neuroimaging studies of the influence of age on the number of presynaptic serotonin transporters (SERT) are controversial. To provide further evidence of relevance for this ongoing discussion, SERT were imaged in 22 persons without neuropsychiatric impairment using [123I]2g-carbomethoxy-3g-(iodophenyl)tropane ([123I]g-CIT) and high-resolution single-photon emission tomography (SPET). The SPET analysis method was based on magnetic resonance image co-registration in order to quantify SERT with acceptable inter- and intra-observer variability. Using this technique, we found a significant age-related decline in the thalamic/hypothalamic and midbrain/upper brainstem SERT density, which was more pronounced than that previously reported in the literature. From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies.