Comparative Effects of Hispidulin, Genistein, and Icariin with Estrogen on Bone Tissue in Ovariectomized Rats

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• 作者：Lijuan Yang (1)
  Zixu Yu (1)
  Haili Qu (1)
  Minmin Li (1)
  
• 关键词：Genistein ; Icariin ; Hispidulin ; Osteoporosis
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：70
• 期：1
• 页码：485-490
• 全文大小：375 KB
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• 作者单位：Lijuan Yang (1)
  Zixu Yu (1)
  Haili Qu (1)
  Minmin Li (1)
  
  1. Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China
  
• ISSN：1559-0283

文摘

Icariin, Genistein, and Hispidulin have been proven to have estrogen-like and antiosteoporotic activity and can be potentially used for the treatment of osteoporosis. The present study found that Icariin, Genistein, and Hispidulin treatments, emulating estrogen, significantly contributed to bone density. Comparative effects of Icariin, Genistein, and Hispidulin with estrogen on in ovariectomized rats were investigated. Our results showed that genistein was found to have superior bone protective effects against osteoporosis among genistein, Icariin, and Hispidulin.