Insulitis in human diabetes: a histological evaluation of donor pancreases

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• 作者：Marcus Lundberg ; Peter Seiron ; Sofie Ingvast ; Olle Korsgren ; Oskar Skog
• 关键词：HLA ; Inflammation ; Insulin secretion ; Insulitis ; Islets ; Macrophages ; T cells ; Type 1 diabetes ; Type 2 diabetes
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：2
• 页码：346-353
• 全文大小：1829KB
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisAccording to the consensus criteria developed for type 1 diabetes, an individual can be diagnosed with insulitis when ≥ 15 CD45+ cells are found within the parenchyma or in the islet–exocrine interface in ≥ 3 islets. The aim of this study was to determine the frequency of individuals with type 2 diabetes fulfilling these criteria with reference to non-diabetic and type 1 diabetic individuals.